Biomedical Potential of Marine Natural Products

Ireland, Chris M.; Copp, Brent R.; Foster, Mark P.; McDonald, Leonard A.; Radisky, Derek C.; Swersey, J. Christopher

doi:10.1007/978-1-4899-2391-2_1

Cited by 98 publications

(83 citation statements)

References 207 publications

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“…At the end of 1990s, the discoveries of bioactive compounds were made by using marine bacteria, invertebrates and algae [3]. Seaweed broadly says algae are a cheap source in the preparation of new chemicals followed by other marine invertebrates [4]. Seaweed played a milestone in pharmaceutical industries as well as modern biology during the year 1980 to 1995.…”

Section: Introductionmentioning

confidence: 99%

Uses of Seaweed and Its Application to Human Welfare: A Review

Pati

Sharma

Nayak

et al. 2016

Int J Pharm Pharm Sci

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Seaweed research has been carried out for more than seven decades by many research workers. Research has been done separately in different aspects accordingly to our need. The main objective of the present review is to gather information relating to nutritional, pharmacological, clinical, biochemical, industrial uses and its application to human welfare. Seaweeds have a high concentration of essential vitamins, trace elements, proteins, lipids, polysaccharides, enzymes, and minerals as compared to terrestrial foodstuffs. These plants have been a source of food, fodder, medicine, cosmetics, energy, fertilizer and are used for industrial production of agar and alginate. Their recent utilization increases in poultry due to their nutritive value. In the present scenario, it is being used for wastewater treatment such as treatment of wastewater to reduce nitrogen and phosphorus containing compounds. This review work is an attempt to highlights all the relevant application and uses of seaweeds and its products. Finally, this paper would be helpful to a common man to know and aware about such a great living resources which is present in and around us.

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Section: Introductionmentioning

confidence: 99%

Uses of Seaweed and Its Application to Human Welfare: A Review

Pati

Sharma

Nayak

et al. 2016

Int J Pharm Pharm Sci

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“…The marine environment is a rich source of both biological and chemical diversity. This diversity has been the source of unique chemical compounds with the potential for industrial development as pharmaceuticals, cosmetics, nutritional supplements, molecular probes, enzymes, fine chemicals, and agrichemicals (Ireland et al, 1993). Hence the present investigation was on the isolation, screening and growth optimization of a potent biocidal bacterium from sediment sample collected from Thengapattanam estuary on the south west coast of India.…”

Section: Introductionmentioning

confidence: 99%

Isolation, screening and growth optimization of antagonistic Bacillus subtilis MS21 from Thengapattanam estuary against plant fungal pathogens

Anjhana¹,

Sasikala²

2017

Int. J. Adv. Res. Biol. Sci.

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In the present work marine sediment samples were collected from Thengapattanam estuary on the south west coast of India for the isolation and screening of bacteria for biocidal potency. The density of the bacterial load in the sediment samples was ranged from 5.43x10 4 to 2.8x10 6 CFU/g. Screening of bacterial isolates for antagonistic activity revealed that the isolate MS21 had the highest zone of clearance among against all the 10 plant fungal pathogens tested. Among 10 fungal pathogens, the highest antagonistic activity was observed against Gleosporium gleosporioide (36mm) and the lowest against Colletotrichum lamella (11mm). The potential isolate was identified as Bacillus subtilis using biochemical methods and it was designated as Bacillus subtilis MS21. Effect of various physicochemical parameters on growth of B. subtilis MS21 showed that 36 hrs of incubation period, 150 rpm agitation, pH-8.0, temperature-35 o C, salinity-1.0%, 2% sucrose as carbon source and 1% beef extract as nitrogen source were found to be the ideal conditions for maximum growth. Maximum growth of 1.92 OD was observed in mass scale culture with the optimized ideal conditions in the shake flask.

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“…24 Many secondary metabolites with unique structural features have been isolated from only a small number of ocean organisms. 25 Therefore, oceans must contain huge supplies of structurally unique secondary metabolites that can be useful as new chemical templates for drug discovery studies, as seen in Table 2 and Figure 3. 25 These few examples demonstrate that the oceans indeed represent an unexploited source of novel compounds with promising applications in medicinal chemistry.…”

Section: Alternative Sources Of Natural Products: a Hope For The Discmentioning

confidence: 99%

Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?

Valli¹,

Pivatto²,

Danuello³

et al. 2012

Quím. Nova

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Recebido em 22/5/12; aceito em 19/7/12; publicado na web em 26/10/12The use of natural products has definitely been the most successful strategy in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. This paper seeks to show the great value of secondary metabolites and emphasize the rich chemical diversity of Brazilian biodiversity. This natural chemical library remains understudied, but can be a useful source of new secondary metabolites with potential application as templates for drug discovery.

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Biomedical Potential of Marine Natural Products

Cited by 98 publications

References 207 publications

Uses of Seaweed and Its Application to Human Welfare: A Review

Uses of Seaweed and Its Application to Human Welfare: A Review

Isolation, screening and growth optimization of antagonistic Bacillus subtilis MS21 from Thengapattanam estuary against plant fungal pathogens

Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?

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