How can computational tools support the proposition of 15-minute cities? This paper examines the implementation of computer-aided approaches that support the analysis and proposition of urban areas where residents can access all their basic needs within a 15-minute walk, bike ride, or public transportation ride—the ultimate goal of a 15-minute city. Although this concept has gained significant attention as a sustainable and equitable urban development model, more efficient implementations require complex spatial and temporal analysis. At the same time, computational approaches such as those within the generative and parametric logic can utilize algorithms to create and test design solutions quickly and efficiently, allowing designers to address a variety of scenarios and options for producing more walkable, integrated, and resilient urban environments. Exploring a systematic review of the scientific literature (n = 244 peer-reviewed empirical studies) on Scopus and Web of Science databases, this paper synthesizes approaches to support the analysis and design of 15-minute cities, emphasizing the use of computer-aided techniques. The work contributes to developing a knowledge base on computational tools for 15-minute cities, highlighting their strengths, limitations, and potential for further development.