We experimentally demonstrate, for the first time, polarization-insensitive wavelength conversion of a 10 Gb/s NRZ-OOK data signal based on four-wave mixing in a silicon nanowire with bit-error rate measurements. , based on different nonlinear effects such as cross-phase modulation (XPM), cascaded second harmonic and difference frequency generation (cSHG/DFG), and four-wave-mixing (FWM). Recently, nonlinear effects in silicon nanowires have attracted considerable research interests due to compactness, large conversion bandwidth and complementary metal-oxide-semiconductor (CMOS) compatibility. Due to the strong light confinement in silicon waveguides with sub-micron dimensions, the group velocity dispersion (GVD), which is a critical parameter for parametric processes, can be engineered and thus one can achieve ultra-broadband wavelength conversion In this paper, we report polarization insensitive AOWC of a 10-Gb/s non-return-to-zero on-off keying (NRZ-OOK) data signal based on FWM in a silicon nanowire. Error-free performance is achieved for the converted signals while the polarization of the input data signal is continuously scrambled.