15 Total Prosthetic Replacement in Rapidly Destructive Arthrosis of the Hip Joint

Postel, M; Kerboull, M.

doi:10.1097/00003086-197009000-00016

Cited by 62 publications

(119 citation statements)

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“…The condition was often described in the early 1970s (1,2). It occurs within months of the onset of symptoms in elderly individuals, mainly women.…”

Section: Discussionmentioning

confidence: 99%

“…Once it occurs, the hip joint is destroyed in a rapid and intensive manner, leading to striking joint deformity. Extensive destruction of the weight-bearing region of the acetabulum, coupled with increased blood loss during surgery, can make joint reconstruction difficult for the surgeon performing a total hip arthroplasty (1,3). There is therefore clearly a need for early diagnosis of this rapidly destructive hip OA.…”

Section: Discussionmentioning

confidence: 99%

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Significant increases in serum and plasma concentrations of matrix metalloproteinases 3 and 9 in patients with rapidly destructive osteoarthritis of the hip

Masuhara

Nakai

Yamaguchi

et al. 2002

Arthritis & Rheumatism

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Objective. Rapidly destructive osteoarthritis (OA) of the hip is an uncommon subset of OA that affects mainly elderly women. Previous studies indicate that elevated levels of matrix metalloproteinases (MMPs) are produced within the tissue of patients with the condition. In the present study, we sought to determine whether serum and plasma levels of MMPs and tissue inhibitors of metalloproteinases (TIMPs) are also elevated.Methods. Blood samples were obtained from 16 patients with rapidly destructive hip OA and from 20 patients with OA before total hip arthroplasty was performed. Synovial specimens were obtained during surgery. Synovial fibroblasts that had migrated sufficiently from explants were subcultured in vitro for 72 hours after confluency, and harvested supernatants were collected. Blood, tissue samples, and fibroblasts were assayed for MMPs 1, 2, 3, and 9, and TIMPs 1 and 2 by sandwich enzyme immunoassay.Results. In blood samples, the levels of MMP-3 and MMP-9 in the group with rapidly destructive hip OA were significantly higher than the normal range and were also significantly higher than those in the OA group. In tissue samples, the levels of MMP-1, MMP-3, MMP-9, and TIMP-1 in the group with rapidly destructive hip OA were significantly higher than those in the OA group. Conclusion.The results of this study show that serum and plasma levels of MMP-3 and MMP-9 are significantly increased in patients with rapidly destructive hip OA. Significantly large amounts of these MMPs produced in synovial tissues within the hip joint could contribute in part to elevation of blood levels. Detection of increased levels of MMP-3 and MMP-9 in patients with painful, disabling hip OA may be of diagnostic value for rapidly destructive hip OA.

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“…The condition was often described in the early 1970s (1,2). It occurs within months of the onset of symptoms in elderly individuals, mainly women.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Significant increases in serum and plasma concentrations of matrix metalloproteinases 3 and 9 in patients with rapidly destructive osteoarthritis of the hip

Masuhara

Nakai

Yamaguchi

et al. 2002

Arthritis & Rheumatism

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“…The most extensive results have been reported for cemented implants [3,5], with no clinical and radiographic series on either hybrid or press-fit implants. One report stated a revision rate without discussing outcomes [6].…”

Section: Introductionmentioning

confidence: 99%

Total Hip Arthroplasty in Rapidly Destructive Osteoarthritis of the Hip: A Case Series

Kuo

Ezzet

Patil

et al. 2009

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

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“…Rapidly destructive osteoarthritis (OA) of the hip is an uncommon subset of OA that affects mainly elderly women and leads to painful disability requiring total joint replacement [17,19,21]. Characteristically, the average duration of symptoms is significant shorter in patients with rapidly destructive OA, and joint-space narrowing has been shown to progress consistently faster, exceeding an annual rate of 2 mm in most patients [15].…”

Section: Introductionmentioning

confidence: 99%

“…On MRI, involvement of the femoral head and the acetabulum exhibiting a bone marrow edema-like pattern can be observed [2]. In advanced stages, destruction of subchondral bone with complete loss of joint space, fragmentation, and subluxation of the joint have been observed [7,19]. Severe destruction of cartilage and bone along with invasion of nonspecific granulation tissue composed of macrophages and fibroblastic cells are consistent histological features, although a potential causative relationship between ischemic necrosis of the femoral head and rapidly destructive OA is still subjected to controversial debates [14,22].…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of serum type I collagen C-telopeptide in patients with rapidly destructive osteoarthritis of the hip

Berger

Kröner

Stiegler

et al. 2004

International Orthopaedics (SICOT)

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We compared type I collagen degradation using serum cross-linking C-terminal telopeptide (ICTP) in 18 patients with rapidly destructive osteoarthrosis and in 20 patients with slowly progressive osteoarthrosis of the hip. The diagnosis was established by clinical examination and radiographic evaluation. Total hip arthroplasty was performed in all patients. Serum levels of ICTP, bone-specific alkaline phosphatase, osteocalcin and N-terminal propeptide were studied. Patients with rapidly destructive osteoarthrosis had higher mean (SD) serum ICTP levels than patients with slowly progressive osteoarthrosis [13.2 (5.6) versus 3.7 ng/ml (1.4), p=0.001] whereas no significant difference of all other markers was seen between the groups. Elevation of ICTP levels correlated significantly with decreased joint-space width assessed by radiographs of the hip (p=0.01). Our data suggest that rapidly destructive hip osteoarthrosis is associated with elevated serum ICTP levels, reflecting increased collagen type I degradation.Résumé Nous avons comparé la dégradation du collagène type I en utilisant le cross-linking du telopeptide Terminal C (ICTP) chez 18 malades avearthrose rapidement destructrice et chez 20 malades avecarthrose lentement progressive de la hanche. Le diagnostic a été établi par examen clinique et évaluation radiographique. L'arthroplastie totale de la hanche a été exécuté chez tous les malades. Le niveau sérique d'ICTP, des phosphatases alcalines osseuse spécifiques, de l'ostéocalcine, et du propeptide N-Terminal a été étudié. Les malades avec arthrose rapidement destructrice avaient une moyenne du niveau d'ICTP nettement plus haute que les malades avec arthrose lentement progressive [13.2 (5.6) vs 3.7 ng/ml (1.4), p=0.001], alors qu'aucune différence notable de tous les autres marqueurs n'a été notée entre les groupes. L'élévation de niveau de l› ICTP était en corrélation avec la hauteur de l'interligne articulaire apprécié par des radiographies (p=0.01). Nos données suggèrent que l'arthrose rapidement destructive est associé à une élévation sérique de l'ICTP reflétant une augmentation de la dé-gradation du collagène de type I.

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15 Total Prosthetic Replacement in Rapidly Destructive Arthrosis of the Hip Joint

Cited by 62 publications

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Significant increases in serum and plasma concentrations of matrix metalloproteinases 3 and 9 in patients with rapidly destructive osteoarthritis of the hip

Significant increases in serum and plasma concentrations of matrix metalloproteinases 3 and 9 in patients with rapidly destructive osteoarthritis of the hip

Total Hip Arthroplasty in Rapidly Destructive Osteoarthritis of the Hip: A Case Series

Elevated levels of serum type I collagen C-telopeptide in patients with rapidly destructive osteoarthritis of the hip

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