1546 Congenital Hypothyroidism: A Review of the Risk Factors

Dalili, Setila; Rezvany, SM; Dadashy, A; Mohamady, Heba M.; Dalili, Hosein; Medghalchy, A; Nezhad, H Gholam; Nezhad, M Mirza; Rokhshad, H

doi:10.1136/archdischild-2012-302724.1546

Cited by 14 publications

(34 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, Dalili et al have reported that the frequency of Normal Vaginal Delivery (NVD) was significantly higher in neonates with CH compared to the normal population (49). It seems that different conditions related to the type of delivery, including the iodine condition of the population, method of delivery and using different disinfectant have an impact on the association of type of delivery and CH occurrence.…”

Section: Discussionmentioning

confidence: 93%

“…By considering the reported group differences, we could design more studies for better understand- ing of different subgroups of CH. As mentioned previously, though there were studies regarding CH-related risk factors (6,34,36,44,47,49,56,59,63) there was no comprehensive review in this field. Moreover, for some important risk factors such as seasonality or gender differences, the results of studies were not in agreement.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Systematic Review on the Risk Factors of Congenital Hypothyroidism

Hashemipour¹,

Samei²,

Kelishadi³

et al. 2019

J. Pediatr. Rev.

View full text Add to dashboard Cite

Context: Congenital Hypothyroidism (CH) is the most common endocrine disorder and causes of preventable mental retardation in children. Objective: We aimed to review the reported CH-related risk factors systematically. Data Sources: In this review, all types of human studies on the risk factors related to the occurrence or high rate of CH were included. An electronic search was conducted in international and national electronic databases. The following keywords were used: "Congenital Hypothyroidism" AND "risk factor".

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

A Systematic Review on the Risk Factors of Congenital Hypothyroidism

Hashemipour¹,

Samei²,

Kelishadi³

et al. 2019

J. Pediatr. Rev.

View full text Add to dashboard Cite

show abstract

“…Several studies have investigated different prognostic factors on CH ( 12 , 13 ). Identification of risk factors for this condition can improve diagnosis or treatment plan of these neonates.…”

Section: Discussionmentioning

confidence: 99%

“…There are some variations in different areas of Iran such as Tehran and Isfahan which found the average prevalence of CH at 1:914 and 1:338 live birth, respectively ( 11 ). Several studies have investigated different prognostic factors of CH ( 12 , 13 ), that indicates the influence of several genetic and environmental factors on the incidence of this disease ( 12 ). More practically, it could be helpful to have a higher index of suspicion for CH in neonates with the identified risk factors.…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with congenital hypothyroidism: a case-control study in southeast Iran

et al. 2018

View full text Add to dashboard Cite

Background and aimCongenital hypothyroidism (CH) is known as one of the most common preventable cause of mental retardation. This study aimed to determine factors associated with CH in Iran.MethodsThis case-control study was conducted on 160 children under one year old in Zahedan in southeast Iran in 2016. The neonates who were born from March 1, 2015 to March 19, 2016 and had undergone a screening program for CH were the study population. The neonates with serum TSH > 10mIu/L and T4 < 6.5 or TSH > 30 mIu/L were considered as a case group. Each case was individually matched for sex, age at birth and place of residence with three neonates with normal TSH and T4 titers as a control group. Data was gathered using a standard checklist and analyzed using SPSS 20 and statistical tests, such as Chi-square and Fisher’s exact tests. Multivariable logistic regression analysis was also used to identify independent predictors of CH.ResultsAbout 25 of the 40 patients with CH (62.5%) were male who, in the univariate analysis, the following explanatory factors had no significant association with CH: history of parental consanguinity, type of delivery, weight at birth, height at birth, age of mother, sampling time, nationality, and birth season (p>0.05). Although, multivariate analysis showed no significant association between the studied factors and risk of CH (p>0.05), the likelihood of CH was greater among neonates born to consanguineous parents (AOR: 1.78, 95% CI: 0.82–3.89), those who were born to lower height at birth (AOR: 1.82, 95% CI: 0.85–3.91), neonates born to mothers younger than 18 years (AOR: 2.43, 95% CI: 0.57–10.29) and those who were born in the summer (AOR: 1.76, 95% CI: 0.57–5.44).ConclusionNone of the studied factors were predictors for CH. Since consanguineous marriages are frequent in the province, and it may be a major contributory factor, future studies should be conducted on the genetic causes.

show abstract

“…Screening programs carried out so far in India to detect incidence of CH are listed in Table 2. All these studies showed that the prevalence of CH is high in India when compared to its worldwide prevalence (1:3000 to 4000) (25)(26)(27). In a country like India, where birth rate is very high, this high prevalence underlines the need for nationwide screening for CH.…”

Section: Congenital Hypothyroidismmentioning

confidence: 99%

Current and future perspective of newborn screening: an Indian scenario

Kaur

Thakur

Kataria

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

Background: Newborn screening comprises a paramount public health program seeking timely detection, diagnosis, and intervention for genetic disorders that may otherwise produce serious clinical consequences. Today newborn screening is part of the health care system of developed countries, whereas in India, newborn screening is still in the toddler stage. Method: We searched PubMed with the keywords newborn screening for metabolic disorders, newborn screening in India, and congenital disorder in neonates, and selected publications that seem appropriate. Results: In India, in spite of the high birth rate and high frequency of metabolic disorders, newborn screening programs are not part of the health care system. At Union Territory, Chandigarh in 2007, newborn screening was initiated and is currently ongoing for three disorders, that is, congenital hypothyroidism, congenital adrenal hyperplasia, and glucose-6-phosphate dehydrogenase (G6PD) deficiency. Prevalence of these disorders is found to be 1:1400 for congenital hypothyroidism, 1:6334 for congenital adrenal hyperplasia, and 1:80 for G6PD deficiency. Conclusion: Mandatory newborn screening for congenital hypothyroidism should be implemented in India, and other disorders can be added in the screening panel on

show abstract

1546 Congenital Hypothyroidism: A Review of the Risk Factors

Cited by 14 publications

References 0 publications

A Systematic Review on the Risk Factors of Congenital Hypothyroidism

A Systematic Review on the Risk Factors of Congenital Hypothyroidism

Risk factors associated with congenital hypothyroidism: a case-control study in southeast Iran

Current and future perspective of newborn screening: an Indian scenario

Contact Info

Product

Resources

About