2016
DOI: 10.1007/s40846-016-0113-4
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16-Channel Surface Coil for 13C-Hyperpolarized Spectroscopic Imaging of Cardiac Metabolism in Pig Heart

Abstract: Abstract\ud Purpose: Magnetic resonance spectroscopy of hyperpolarized 13C pyruvate and its\ud metabolites in large animal models is a powerful tool for assessing cardiac metabolism in\ud patho-physiological conditions. In 13C studies the Signal-to-Noise Ratio (SNR) could be\ud crucial, to overcome intrinsic data quality limitation due to the low molar concentration of\ud certain metabolites as well as the low flux of conversion. On the other hand, since 13C-MRS\ud is essentially a semi-quantitative technique,… Show more

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Cited by 6 publications
(5 citation statements)
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“…Coil #5 is a commercial 16-channel receive-only array (RAPID Gmbh, Rimpar, Germany), made of rectangular loops of approximately 60x130 mm 2 , with a similar design to [17] . The array is divided in two separate modules: a rigid module placed below the sample and a flexible module placed above the sample.…”
Section: Methodsmentioning
confidence: 99%
“…Coil #5 is a commercial 16-channel receive-only array (RAPID Gmbh, Rimpar, Germany), made of rectangular loops of approximately 60x130 mm 2 , with a similar design to [17] . The array is divided in two separate modules: a rigid module placed below the sample and a flexible module placed above the sample.…”
Section: Methodsmentioning
confidence: 99%
“…Despite these advances, currently there is no available clinical method to effectively determine pH in the heart noninvasively. Hyperpolarized [1-13 C]pyruvate has been previously used to observe rapid metabolic processes, specifically the production of hyperpolarized [1-13 C]lactate and [ 13 C]bicarbonate, in real time in the rat heart ex vivo 13,14,[28][29][30][31][32][33][34][35][36][37] and in vivo, [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] in the pig heart in vivo, 45,[51][52][53][54][55][56][57][58] and recently also in the human heart in vivo. 59,60 In these previous studies, metabolic markers of heart failure, 40 acute infarction, 36 cardiac hypertrophy, 61 ischemic heart 42 and ischemia-reperfusion injury 49 have been described.…”
Section: Introductionmentioning
confidence: 99%
“…A multiple-channel surface coil provides a high SNR close to the coil surface but a non-uniform sensitivity in depth, while volumetric coils provide a uniform sensitivity over the FOV, at the cost of lower SNR. An example of the performance of a flexible 16-channel phased array coil for application in pig heart studies was reported, assessing both SNR and signal uniformity in phantom and animal experiments [80].…”
Section: C Radiofrequency Coilsmentioning
confidence: 99%