160. Sucrose-based preservation solution modified by PEG-8000 for cold storage of isolated rat liver

Semenchenko, Olga A.; Cherkashina, Daria V.; Tkacheva, Elena N.; Lebedinsky, Alexander S.; Fuller, Barry; Petrenko, Alexander

doi:10.1016/j.cryobiol.2006.10.161

Cited by 4 publications

(2 citation statements)

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“…Application of PEG with relatively low molecular masses might be beneficial in transplantation applications. Addition of 1% PEG-8000 to sucrose-based balanced salt solution (SBS) improved biochemical indices during cold storage of rodent livers [67]. Protective action of PEG 8000 is supported by results of rabbit renal transplantation using SBS.…”

Section: University Of Wisconsin Solutionmentioning

confidence: 75%

Organ Preservation: Current Concepts and New Strategies for the Next Decade

Guibert

Petrenko

Balaban

et al. 2011

Transfus Med Hemother

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287

233

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Organ transplantation has developed over the past 50 years to reach the sophisticated and integrated clinical service of today through several advances in science. One of the most important of these has been the ability to apply organ preservation protocols to deliver donor organs of high quality, via a network of organ exchange to match the most suitable recipient patient to the best available organ, capable of rapid resumption of life-sustaining function in the recipient patient. This has only been possible by amassing a good understanding of the potential effects of hypoxic injury on donated organs, and how to prevent these by applying organ preservation. This review sets out the history of organ preservation, how applications of hypothermia have become central to the process, and what the current status is for the range of solid organs commonly transplanted. The science of organ preservation is constantly being updated with new knowledge and ideas, and the review also discusses what innovations are coming close to clinical reality to meet the growing demands for high quality organs in transplantation over the next few years.

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Section: University Of Wisconsin Solutionmentioning

confidence: 75%

Organ Preservation: Current Concepts and New Strategies for the Next Decade

Guibert

Petrenko

Balaban

et al. 2011

Transfus Med Hemother

Self Cite

287

233

View full text Add to dashboard Cite

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“…It is nontoxic and has been applied in biomedical research as drug-delivery system, tissue engineering scaffolds, etc. PEG has been also included in solutions for hypothermic storage of kidney and liver [112,113]. There were several studies describing cryopreservation of red blood cells [114], pancreatic islets [115,116] and vein grafts with PEG alone [117].…”

Section: Supplementation Of Dmso With High Molecular Weight Macromoleculesmentioning

confidence: 99%

Dimethyl Sulfoxide: A Central Player Since the Dawn of Cryobiology, is Efficacy Balanced by Toxicity?

et al. 2020

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Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bone marrow and blood cells until needed for transfusion. Nevertheless, its effects on cell biology and apparent toxicity in patients have been an ongoing topic of debate, driving the search for less cytotoxic cryoprotectants. This review seeks to place the toxicity of DMSO in context of its effectiveness. It will also consider means of reducing its toxic effects, the alternatives to its use and their readiness for active use in clinical settings.

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