167. Synthetic antimalarials. Part XVII. Some aminoalkylaminoquinoline derivatives

Substituted Quinolinones, Part 10: Synthesis of Angular Tetracyclic Thieno and Thiopyrano[3,2-c]benzo[h]quinolinones Under PTC Conditions as Novel Enzymatic Enhancers

“…The synthetic route includes SCHEME 1 Downloaded by [Northeastern University] at 01:07 21 November 2014 chlorination of the starting material 1, using a mixture of phosphoryl chloride and phosphorus pentachloride to obtain the 2,4-dichloro derivative 2 17 in a 68% yield. Hydrolysis of compound 2 was attempted in both acid and alkaline media.…”

Synthesis of novel phenyl substituted dibenzonaphthyridines

“…It was assumed that the reluctance of the reaction of 2-[(2-benzoyl-4-chlorophenyl)amino]-4-chloroquinolines (2) to proceed at lower temperature might be due to the deactivating nature of the chloro group which inhibits the …”

“…(2a-d): general procedure The 2,4 mmol) was heated with 2-amino-5-chlorobenzophenone (4 mmol or excess) under neat conditions at 160 °C for 30 min. The product was washed with water, dried, and purified using silica gel column chromatography eluting with petroleum ether:ethyl acetate mixture (98:2) to obtain 2 which was recrystallised from methanol.…”

Benzoquinoline amines – Key intermediates for the synthesis of angular and linear dinaphthonaphthyridines

“…For instance, quinoline based chemical entities were known for their anti-tuberculosis [1,2] , antiproliferative [3,4] , anthelmintic [5] , antibacterial [6] and antioxidant activities [7] . 4-Amino-7-chloroquinoline derivatives and its modified side-chain analogs [8–10] were representative class of antimalarial drugs. Extensive studies were made to obtain biologically active quinolines and naphthyridine analogues starting from chloro quinolines [11] .…”