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The effects on activity against Schistosoma mansoni of further modifications of the diaminodiphenoxyalkanes are reported. Replacement of the amino‐group by any of a large number of other groups destroys activity. Activity is retained in the presence of certain substituted (hydroxyalkyl, carboxyalkyl) amino‐groups and in some of their aldehyde‐bisulphite derivatives. Many variations of the central chain lead to compounds of reduced activity, the outstanding exceptions being a number of but‐2‐ene derivatives, which retain full activity.

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Raison : Preparation and Reactions of 558. Preparation and Reactions of Thiocurbamoyland T hiour eidoamidines .