The effects on activity against Schistosoma mansoni of further modifications of the diaminodiphenoxyalkanes are reported. Replacement of the amino‐group by any of a large number of other groups destroys activity. Activity is retained in the presence of certain substituted (hydroxyalkyl, carboxyalkyl) amino‐groups and in some of their aldehyde‐bisulphite derivatives. Many variations of the central chain lead to compounds of reduced activity, the outstanding exceptions being a number of but‐2‐ene derivatives, which retain full activity.

Opera-glass hand, la main en lorgnette, has been described as a very rare condition. The term has been used only occasionally, but the disease to which it refers is neither so rare nor of such recent origin as is usually assumed. The present paper calls attention to reports of the same disorder under a variety of names, and describes eight additional cases from the authors' experience. Cases from the Literature.-Marie and Leri (1913) described a 66-year-old woman with curious deformities of the hands. She had had severe generalized rheumatoid arthritis (rhumatisme deformant generalise) for 28 years. Photographs of the hands showed that the fingers and wrists were shortened and contracted and the skin wrinkled, redundant, and thrown into transverse folds, giving the impression that the phalanges were retracted one into the other like an opera glass (les phalanges etaient rentrees en lorgnette les unes dans les autres). Dissection revealed that the phalanges had lost their normal shape, the regular cylinders had become irregular truncated cones, the articular ends had completely disappeared. These changes had been seen in a radiograph which showed similar absorption of bone at the distal ends of the radii, ulni, carpals, and metacarpals, and marked radiolucence of all the bones. Microscopic examination showed massive degeneration of bones, cartilage, and muscles sparing only the blood vessels, nerves, and tendons. The authors mentioned another patient with a similar deformity limited to one finger.The term " doigts en lorgnette " was used by Brumpt (1906) to describe a deformity seen in a Sudanese Negro. The history was unreliable because of the ignorance and superstition of the patient and his associates. A line drawing of the hands showed most of the fingers to be markedly shortened, the skin soft and redundant, and the bones obviously shortened and distorted. The author stated that the fingers could be drawn out like a lorgnette and made to assume their normal length. The right ring finger and the left thumb and little fingers were normal. The hands were useless and the muscles were weak but not paralysed. Weigeldt (1929) described a 64-year-old woman with " mains en lorgnette" whose arthritis began at 46. The photograph showed hands similar to those described by Marie and LUri. The published radiograph showed extensive bone destruction. A case published by Nelson (1938) showed similar areas of bone destruction and absorption. A parathyroid adenoma was discovered at autopsy,

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