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Novel 2-substituted-quinoxaline analogs with potential antiproliferative activity against breast cancer: insights into cell cycle arrest, topoisomerase II, and EGFR activity

“…22 On the other hand, etoposide, doxorubicin, and epirubicin are all examples of topoisomerase II (Topo II) inhibitors. 23 Due to its potential role as a therapeutic target and prognostic marker, Topo II has received a great deal of attention in the context of breast cancer. 24 Topo II exists in two forms, called Topo IIα and Topo IIβ.…”