17β-oestradiol inhibits ferroptosis in the hippocampus by upregulating DHODH and further improves memory decline after ovariectomy

Multienzyme Active Manganese Oxide Alleviates Acute Liver Injury by Mimicking Redox Regulatory System and Inhibiting Ferroptosis

“…[ 23 ] Ammonium ferric citrate (FAC) is a physiological form of non‐ferritin‐bound iron that causes intracellular iron overload and leads to ferroptosis. [ 24 ] Initially, we used RSL3 to induce ferroptosis in primary hepatocytes and observed that MnO 2 Nfs significantly alleviate RSL3‐mediated reduction in GSH ( Figure A). Simultaneously, MnO 2 Nfs attenuated the elevation of Fe 2+ and cellular total ROS induced by RSL3 (Figure 5B,C,G,H).…”

“…The Biodistribution of Manganese In Vivo: To assess the accumulation of MnO 2 Nfs in major organs including the heart, liver, spleen, lung, and kidney, a group of healthy mice (n = 5) was intravenously injected with MnO 2 Nfs at a dose of 10 mg kg −1 in a volume of 200 μL. Subsequently, at various time points (3,12,24,48, and 72 h), the mice were sacrificed to harvest the major organs for further analysis. [41] The manganese (Mn) content in the main organs was determined by ICP-MS after nitric acid digestion.…”

Mapping the 5-HTergic neural pathways in perimenopausal mice and elucidating the role of oestrogen receptors in 5-HT neurotransmission

“…Limitations: The present study showed that the hypoestrogenic state after OVX alters 5-HT-related receptor expression in the brain by affecting the levels of the ligand 5-HT. Previous studies have suggested that oestrogen receptors are widely distributed in the brain and may directly affect neurons in various brain regions, for example, by inducing ferroptosis [ 56 ] and neuroinflammatory responses [ 57 ]. From the current CUT&Tag results, it is possible that 5-HT2AR may be transcriptionally regulated by ERα and ERβ (data not shown), although this has not been validated at the cellular and animal levels.…”

17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

“…Vaginal smears of 14 consecutive days were used to forecast the hormonal status and estrous cycle changes before and after surgery. The protocol conformed to previously reported protocols [ 18 ]. During the whole research period, the rats were checked daily, and their body weight was recorded weekly.…”