2010
DOI: 10.1016/j.pbb.2010.05.002
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18-Methoxycoronaridine, a potential anti-obesity agent, does not produce a conditioned taste aversion in rats

Abstract: 18-Methoxycoronaridine (18-MC), a selective antagonist of α3β4 nicotinic receptors, has been shown to reduce the self-administration of several drugs of abuse. Recently, this agent has also been shown to attenuate sucrose reward, decrease sucrose intake and prevent the development of sucrose-induced obesity in rats. The present experiments were designed to determine whether the latter effect was due to an 18-MC-induced conditioned taste aversion to sucrose. Both 18-MC (20 mg/ kg, i.p.) and control agent, lithi… Show more

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Cited by 2 publications
(2 citation statements)
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“…While 18-MC has been shown to reduce self-administration of multiple drugs of abuse via the habenulo–interpeduncular pathway (e.g., Glick et al 2008), 18-MC, like other nicotinic receptor antagonists, may modulate the effects of ghrelin via a distinct mechanism. Considered together with our previous data showing attenuated sucrose reward following 18-MC treatment (Taraschenko et al 2010a, b) and recent studies implicating ghrelin in both food and drug reward (Jerlhag et al 2010), these findings indicate that α3β4 nicotinic receptors and ghrelin could be jointly involved in the regulation of food reward and drug addiction.…”
Section: Discussionsupporting
confidence: 73%
See 1 more Smart Citation
“…While 18-MC has been shown to reduce self-administration of multiple drugs of abuse via the habenulo–interpeduncular pathway (e.g., Glick et al 2008), 18-MC, like other nicotinic receptor antagonists, may modulate the effects of ghrelin via a distinct mechanism. Considered together with our previous data showing attenuated sucrose reward following 18-MC treatment (Taraschenko et al 2010a, b) and recent studies implicating ghrelin in both food and drug reward (Jerlhag et al 2010), these findings indicate that α3β4 nicotinic receptors and ghrelin could be jointly involved in the regulation of food reward and drug addiction.…”
Section: Discussionsupporting
confidence: 73%
“…Specifically, 18-MC appears to increase satiety in animals consuming palatable food while having no effect on consumption of normal chow and water (Taraschenko et al 2008). Furthermore, 18-MC has a safe side effect profile (Maisonneuve and Glick 2003) and does not produce a conditioned taste aversion in rats (Taraschenko et al 2010a). …”
Section: Introductionmentioning
confidence: 99%