18F-DOPA uptake does not correlate with IDH mutation status and 1p/19q co-deletion in glioma

Is IDH mutation status associated with 18F-FDopa PET uptake?

“…This was applied in order to be the closest possible to the methodology utilized by Cicone et al in their publication so as to avoid any methodological bias when comparing the two diferent populations. In addition, this VOI defnition is in accordance with that recently proposed by the same group in response to the European/American guidelines [1,5]. When considering our whole population including both difuse gliomas and glioblastomas, we found that static parameters failed to diferentiate IDH-mutant from IDHwildtype gliomas (p=0.69 for the TBRmean and p=0.53 for MTV).…”

“…This fnding has been observed in two diferent studied populations [2,4]. By contrast, as stated by Cicone et al, this relationship cannot be extended to a population including both difuse gliomas and glioblastomas [1]. Predicting the IDH mutation status in the subgroup of difuse gliomas is particularly useful from a clinical standpoint since glioblastomas can often be identifed owing to contrast enhancement on contrast-enhanced T1-weighted MRI.…”

“…Dear Sir, We read with great interest the recent article by Cicone et al published in the Annals of Nuclear Medicine [1]. The authors state that 6-[18F]fuoro-l-DOPA (18F-FDopa) PET uptake is not signifcantly diferent between IDH-mutant and IDH-wildtype gliomas in a population composed of diffuse gliomas as well as glioblastomas.…”

“…Specifcally, the MTV was signifcantly higher in IDH-mutant difuse gliomas (p=0.002) while a substantial trend toward a higher TBRmean in these IDH-mutant difuse gliomas was also observed (p=0.10). We then recalculated the data from Cicone et al's cohort [1]. Unfortunately, after excluding glioblastomas, although the mean MTV was higher in IDH-mutant than in IDHwildtype difuse gliomas (19.4 mL vs. 10.4 mL), this observation was not statistically signifcant.…”

“…Firstly, Cicone et al did not use a fxed threshold to segment their tumor volume, leading to MTVs which were hardly comparable. Secondly, in the publication by Cicone et al, most patients underwent their stereotaxic biopsy prior to having undergone their 18F-FDopa PET, which can afect tumor uptake by removing a portion of the tumor (94% in [1] vs. 2% in [2] and 12% in [4]).…”