18F-FDG PET/CT in Sporadic Creutzfeldt-Jakob Disease

Zizi, G.; Berger, Henri; Lalire, P.; Dejust, S.; Morland, David

doi:10.1097/rlu.0000000000003059

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…En cuanto a la 18 F-FDG-PET/TC, se han señalado hallazgos característicos que se pueden encontrar incluso antes de observarse anomalías en la RM (2) y consisten en áreas hipometabólicas en las zonas afectadas, generalmente bilaterales y asimétricas. La región temporal medial, el cerebelo y los ganglios basales con frecuencia se encuentran menos comprometidos (1,7).…”

Section: Discussionunclassified

Aporte de la 18F-FDG PET/TC en la enfermedad de Creutzfeldt-Jakob esporádica

González¹,

González

Restrepo

et al. 2021

Rev. colomb. radiol.

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La enfermedad de Creutzfeldt-Jakob esporádica (ECJe) es un trastorno neurodegenerativo transmisible extremadamente raro, caracterizado por demencia rápidamente progresiva. En la tomografía por emisión de positrones con 18F-fluoro-2-desoxi-D-glucosa (FDG-PET) de estos pacientes se ha descrito hipometabolismo cortical bilateral parietal, frontal y occipital, sin alteraciones en el cerebelo ni en los ganglios basales, lo que podría contribuir con el diagnóstico diferencial de demencia rápidamente progresiva. Se presenta el caso de un hombre de 75 años, con antecedente de cáncer de próstata y trastorno afectivo bipolar, con dos semanas de cambios comportamentales y anímicos, déficit cognitivo, alucinaciones visuales y auditivas y desorientación espacial con rápida progresión; posteriormente presentó marcha lenta, temblor en miembros inferiores y Babinski derecho. La resonancia (RM) cerebral contrastada mostró restricción a la difusión en corteza frontal bilateral, corteza temporal y giro del cíngulo, con diagnóstico de síndrome paraneoplásico versus enfermedad por priones; FDG-PET con hipometabolismo en la corteza frontal bilateral y lóbulo temporal y parietal derechos. La medición de la proteína 14-3-3, proteína T-Tau y conversión de proteína priónica inducida por agitación en tiempo real (RT-QUIC) en líquido cefalorraquídeo confirma el diagnóstico de enfermedad por priones.

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Section: Discussionunclassified

Aporte de la 18F-FDG PET/TC en la enfermedad de Creutzfeldt-Jakob esporádica

González¹,

González

Restrepo

et al. 2021

Rev. colomb. radiol.

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“…Although initial DWI (A) showed no significant lesions on cortex or basal ganglia, dual FP-CIT PET shows showed hypometabolism in the bilateral occipitoparietal, basal ganglia, and thalamus on early phase (B) with diffuse decreased DAT uptake in delayed phase (C) (more affected on right), which is different of typical corticobasal syndrome. 4,5 Follow-up brain MRI (2 weeks later) showed high signal intensity lesions in cortex and basal ganglia on DWI (D) corresponding to hypoperfusion area of initial early phase FP-CIT PET. CSF studies 14-3-3 protein assay showed positive result.…”

Section: Figurementioning

confidence: 99%

Dual-Phase 18F-FP-CIT PET in 2 Different Clinical Phenotypes of Sporadic Creutzfeldt-Jakob Disease

et al. 2022

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Early diagnosis of Creutzfeldt-Jakob disease (CJD) patients is often challenging due to the low sensitivity of the current clinical diagnostic criteria. We describe MRI and dual-phase 18 F-FP-CIT PET findings in 2 cases of sporadic CJD presenting different clinical phenotypes (Heidenhain variant and corticobasal syndrome). Our case series suggest that dual-phase FP-CIT-PET findings may improve the diagnosis of CJD by combining the perfusion patterns in early phase with the dopamine transporter density in delayed phase. Familiarity with these dual-phase FP-CIT PET findings is helpful for early correct diagnosis of CJD.

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“…In contrast to extensive structural neuroimaging data, limited information is available about the characteristics and diagnostic utility of metabolic brain imaging. Case reports [10–13] and small case series [14–16] showed pronounced hypometabolism in various cortical and subcortical areas in CJD patients. The hypometabolic brain areas were concordant with MRI changes but more pronounced [16, 17].…”

Section: Introductionmentioning

confidence: 99%

Sporadic Creutzfeldt–Jakob disease is associated with reorganization of metabolic connectivity in a pathological brain network

Rus

Mlakar

Ležaič

et al. 2023

Euro J of Neurology

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Background and purpose: Although sporadic Creutzfeldt-Jakob disease (sCJD) is a rare cause of dementia, it is critical to understand its functional networks as the prion protein spread throughout the brain may share similar mechanisms with other more common neurodegenerative disorders. In this study, the metabolic brain network associated with sCJD was investigated and its internal network organization was explored. Methods:We explored 2-[ 18 F]fluoro-2-deoxyd-glucose positron emission tomography (FDG-PET) brain scans of 29 sCJD patients, 56 normal controls (NCs) and 46 other dementia patients from two independent centers. sCJD-related pattern (CJDRP) was identified in a cohort of 16 pathologically proven sCJD patients and 16 age-matched NCs using scaled subprofile modeling/principal component analysis and was prospectively validated in an independent cohort of 13 sCJD patients and 20 NCs. The pattern's specificity was tested on other dementia patients and its clinical relevance by clinical correlations. The pattern's internal organization was further studied using graph theory methods. Results:The CJDRP was characterized by relative hypometabolism in the bilateral caudate, thalami, middle and superior frontal gyri, parietal lobe and posterior cingulum in association with relative hypermetabolism in the hippocampi, parahippocampal gyri and cerebellum. The pattern's expression significantly discriminated sCJD from NCs and other dementia patients (p < 0.005; receiver operating characteristic analysis CJD vs. NCs area under the curve [AUC] 0.90-0.96, sCJD vs. Alzheimer's disease AUC 0.78, sCJD vs. behavioral variant of frontotemporal dementia AUC 0.84). The pattern's expression significantly correlated with cognitive, functional decline and disease duration. The metabolic connectivity analysis revealed inefficient information transfer with specific network reorganization. Conclusions:The CJDRP is a robust metabolic biomarker of sCJD. Due to its excellent clinical correlations it has the potential to monitor disease in emerging disease-modifying trials.

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18F-FDG PET/CT in Sporadic Creutzfeldt-Jakob Disease

Cited by 4 publications

References 10 publications

Aporte de la 18F-FDG PET/TC en la enfermedad de Creutzfeldt-Jakob esporádica

Aporte de la 18F-FDG PET/TC en la enfermedad de Creutzfeldt-Jakob esporádica

Dual-Phase 18F-FP-CIT PET in 2 Different Clinical Phenotypes of Sporadic Creutzfeldt-Jakob Disease

Sporadic Creutzfeldt–Jakob disease is associated with reorganization of metabolic connectivity in a pathological brain network

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