18F-FDG pet/ct/mri fusion images showing cranial and peripheral nerve involvement in neurolymphomatosis

Abstract

We report a 56-year-old female patient with non-Hodgkin's diffuse large B cell lymphoma (NHL) who, on magnetic resonance imaging (MRI) with a T1 weighted and gadolinium-enhanced imaging, was found to have thickening and infiltration in 75% of peripheral nerves of the patient and enlargements of cranial nerves, possibly related to lymphomatous infiltration. Subsequent positron emission tomography/computed tomography (PET/CT) using 18F-labeled 2-deoxy-2-fluoro-d-glucose (18F-FDG) showed widespread active involvement of the cervical plexus, bilateral peripheral nerves, right femoral nerve, the parasellar region of the skull, and marked hypermetabolism in the left trigeminal ganglia. This case re-emphasizes that while CT and MRI provide anatomical details, 18F-FDG PET/CT images better delineate the metabolic activity of neurolymphomatosis (NL) in the peripheral and central nervous system.

TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway

“…This paper indicated that overexpression of TRIM3 could reduce apoptosis, MMP and the production of ROS in PD. PD is a common chronic progressive neurological degenerative disease, with a pathological feature characterized by the absence of dopaminergic neurons in the dense substantia nigra of the brain [ 15 , 16 ]. By unremitting efforts of researchers, several major pathogenesis of PD have been revealed, including mitochondrial dysfunction, oxidative stress, neuroinflammatory response, excitotoxicity, apoptosis, etc.…”

A Case Series of Neurolymphomatosis

“…[ 10 ] FDG PET/CT neurography better illustrates peripheral neuropathy and its extent. [ 15 16 17 18 19 20 ] Identifying extra-neural disease sites was another incremental value of FDG PET/CT scan.…”

Diagnóstico de neurolinfomatosis como complicación tardía de linfoma no Hodgkin por 18F-FDG PET-CT

“…El rendimiento diagnóstico de 18 F-FDG PET/CT se estima en 84% (8), especialmente en compromiso de neuropatía periférica. Algunas presentaciones de casos han reportado el rendimiento del 18 F-FDG PET/CT en el diagnóstico y en la progresión o la respuesta a tratamiento, lo que permite una evaluación completa de cuerpo entero y definir las estructuras comprometidas (10,(12)(13)(14)(15). La RM puede detectar con mayor certeza compromiso de los pares craneanos, pero no siempre en neuropatía periférica.…”