1958 Revision of diagnostic criteria for rheumatoid arthritis

Ropes, Marian W.; Bennett, Granville A.; Cobb, Sidney; Jacox, Ralph F.; Jessar, Ralph A.

doi:10.1002/1529-0131(195902)2:1<16::aid-art1780020104>3.0.co;2-9

Cited by 856 publications

(459 citation statements)

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“…The RA patients were nine females and four males, age from 21 to 66 yr (mean, 48 yr), all had clinically active, classic seropositive RA, as defined by ARA criteria (12). Serum RF titer ranged from 1 :80 to 1 :10,240.…”

mentioning

confidence: 99%

Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis.

Burastero

Casali

Wilder

et al. 1988

The Journal of Experimental Medicine

257

129

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In patients with rheumatoid arthritis (RA), circulating CD5+ B lymphocytes, but not CD5- B lymphocytes, are increased in number and size, exist in an activated state, spontaneously proliferate, and secrete Ig that binds to the Fc fragment of IgG. By constructing continuous mAb-secreting cell lines from CD5+ B lymphocytes, the properties and dissociation constants (Kd) of these antibodies were determined. Two types of rheumatoid factors (RFs) with discrete reactivities were produced. The first type is polyreactive and binds with relatively low affinity (Kd, 10(-5) mol/liter) to the Fc fragment of IgG. These antibodies are similar to those produced by CD5+ B cells from healthy subjects. The second type of RF is monoreactive and binds with higher affinity (Kd, 10(-7) mol/liter) to the Fc fragment of IgG. These latter autoantibodies are produced by CD5+ B cells of RA patients, but not healthy subjects. Long-term longitudinal studies are needed to determine the role of these two types of RFs in the pathogenesis of RA.

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mentioning

confidence: 99%

Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis.

Burastero

Casali

Wilder

et al. 1988

The Journal of Experimental Medicine

257

129

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“…These findings have generally been based on patients with certain forms of the disease. in particular erosive or classic and definite RA as assessed by the American Rheumatism Association (ARA) criteria (5). RA is known to include a heterogeneous group of conditions with a highly variable outcome and response to treatment.…”

mentioning

confidence: 99%

Association of HLA‐DR4/Dw4 and DR2/Dw2 with radiologic changes in a prospective study of patients with rheumatoid arthritis

Young

Jaraquemada

Awad

et al. 1984

Arthritis & Rheumatism

116

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Patients admitted to a prospective study within a year of onset of suspected rheumatoid arthritis showed a positive correlation between HLA-Dw4 and the eventual severity of peripheral radiologic changes. Dw4 and DR4 were strongly associated with severity of erosions when analysis was restricted to each of the following: patients with erosions, those under 50 at onset, and all females. Relationships were consistently stronger with Dw4 than with DR4. Another D-related specificity, MT3, was positively correlated and Dw2/DR2 negatively correlated with erosions.

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“…The sample of gold-tfeated, white patients was drawn from the outpatient and inpatient facilities of the Division of Clinical Immunology and Rheumatology at the University of Alabama in Birmingham. All patients with either classic or definite RA by American Rheumatism Association criteria (14) who were undergoing chrysotherapy were invited to participate. After an interview and a signed informed consent form were obtained, blood was drawn for HLA typing.…”

Section: Methodsmentioning

confidence: 99%

Dr Antigens and Gold Toxicity in white rheumatoid arthritis patients

Barger

Acton

Koopman

et al. 1984

Arthritis & Rheumatism

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An increase in the frequency of DR3 in rheumatoid arthritis (RA) patients exhibiting toxic reactions to chrysotherapy has been reported in several studies of white patients. This study was designed to compare DR antigen frequencies in local white RA patients undergoing chrysotherapy with their response to treatment. The results from our sample of RA patients (n = 148) confirm the fact that there is increased frequency of DR3 in patients who develop toxic reactions to gold therapy, as reported in other studies of white patients. The DR3 increase was attributable to those gold‐treated patients who developed proteinuria, and was not observed in patients who developed skin toxicity. Interestingly, the associations were not as strong as those found in other reports. Only 21.1% of the patients with DR3 manifested toxic reactions overall, with only one‐third of the patients with proteinuria being DR3 positive. There was also an association of toxicity, albeit not significant, with a decreased frequency of DR2, which is consistent with the suggestion that this phenotype may protect against adverse reactions to gold treatment. These results suggest that while DR3 is significantly associated with adverse response to gold treatment, the relationship is not as strong as that previously reported. Explanation of these differences remains to be elucidated.

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1958 Revision of diagnostic criteria for rheumatoid arthritis

Cited by 856 publications

References 1 publication

Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis.

Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis.

Association of HLA‐DR4/Dw4 and DR2/Dw2 with radiologic changes in a prospective study of patients with rheumatoid arthritis

Dr Antigens and Gold Toxicity in white rheumatoid arthritis patients

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