1H MRS studies in the Finnish boron neutron capture therapy project: Detection of 10B-carrier, l-p-boronophenylalanine-fructose

Timonen, Marjut; Kankaanranta, Leena; Lundbom, Nina; Collan, Juhani; Kangasmäki, Aki; Kortesniemi, Mika; Häkkinen, Anna‐Maija; Lönngren, A.; Karjalainen, Sakari; Rasilainen, Merja; Leinonen, J.; Huitti, T.; Jääskeläinen, Juha E.; Kouri, Mauri; Savolainen, Sauli; Heikkinen, Sami

doi:10.1016/j.ejrad.2005.03.017

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…In three patients, the signals in the aromatic region of tumour spectrum were detected. It appears that in favourable cases, it is possible to detect BPA in vivo after the BPA-F infusion or after the BNCT [138] (Fig. 3 and Fig.…”

Section: Molecular Based Boron Imagingmentioning

confidence: 98%

Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

et al. 2013

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Section: Molecular Based Boron Imagingmentioning

confidence: 98%

Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

et al. 2013

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“…Several studies have been described on phantoms [54] or in rodents [55] for BNCT purposes. Timonen et al reported the Finnish feasibility study in 2 patients with brain tumors, evidencing some difficulties in the localization of the [ 19 F]FBPA [56] using MRI. This study should include more patients to conclude about the relevance of such investigation before and after infusion of BPA solution in patients [11].…”

Section: Further Diagnostic Possibilities For Theranostic Approaches In Bnctmentioning

confidence: 99%

Theranostics in Boron Neutron Capture Therapy

Sauerwein

Sancey

Hey‐Hawkins

et al. 2021

Life

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Boron neutron capture therapy (BNCT) has the potential to specifically destroy tumor cells without damaging the tissues infiltrated by the tumor. BNCT is a binary treatment method based on the combination of two agents that have no effect when applied individually: 10B and thermal neutrons. Exclusively, the combination of both produces an effect, whose extent depends on the amount of 10B in the tumor but also on the organs at risk. It is not yet possible to determine the 10B concentration in a specific tissue using non-invasive methods. At present, it is only possible to measure the 10B concentration in blood and to estimate the boron concentration in tissues based on the assumption that there is a fixed uptake of 10B from the blood into tissues. On this imprecise assumption, BNCT can hardly be developed further. A therapeutic approach, combining the boron carrier for therapeutic purposes with an imaging tool, might allow us to determine the 10B concentration in a specific tissue using a non-invasive method. This review provides an overview of the current clinical protocols and preclinical experiments and results on how innovative drug development for boron delivery systems can also incorporate concurrent imaging. The last section focuses on the importance of proteomics for further optimization of BNCT, a highly precise and personalized therapeutic approach.

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Boron detection from blood samples by ICP‐AES and ICP‐MS during boron neutron capture therapy

Linko

Revitzer²,

Zilliacus

et al. 2008

Scandinavian Journal of Clinical and Laboratory Investigation

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Boron concentration analysed from whole blood samples with ICP-AES correlated well with the values of ICP-MS with wet-ashing of the sample matrix, which is generally considered the reference method. When using these methods in parallel at certain intervals during the treatments, reliability of the blood boron concentration values remains satisfactory, taking into account the required accuracy of dose determination in the irradiation of cancer patients.

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1H MRS studies in the Finnish boron neutron capture therapy project: Detection of 10B-carrier, l-p-boronophenylalanine-fructose

Cited by 5 publications

References 23 publications

Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

Theranostics in Boron Neutron Capture Therapy

Boron detection from blood samples by ICP‐AES and ICP‐MS during boron neutron capture therapy

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