1H NMR-based metabolomic study of the effects of flavonoids on citrinin production by Monascus

He, Shanshan; Wang, Yanling; Xie, Mingyong; Gao, Heng; Li, Xiujiang; Huang, Zhibing

doi:10.1016/j.foodres.2020.109532

Cited by 15 publications

(12 citation statements)

References 39 publications

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“…R 2 indicates the ability of PCs to explain the variation in a variable and Q 2 is the predictability of the model. R 2 and Q 2 closing to 1.0 demonstrates that the model is reliable and has good fitting accuracy [36]. HCA was also carried out by SIMCA-P software with the first four principal components of PCA model.…”

Section: Discussionmentioning

confidence: 94%

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1H NMR Combined with Multivariate Statistics for Discrimination of Female and Male Flower Buds of Populus tomentosa

et al. 2021

Molecules

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1H Nuclear Magnetic Resonance (1H NMR) combined with multivariate statistics was adopted to discriminate female and male flower buds of Populus tomentosa in the study. Samples of 11 female and 16 male flower buds of P. tomentosa were collected in Beijing, China. 1H NMR spectra were acquired on a 400 MHz spectrometer. In total, 30 chemical compounds were identified with standards and literature according to chemical shifts, peak areas, and multiplicity. Principal component analysis (PCA), hierarchical clustering analysis (HCA), and supervised orthogonal partial least squares-discriminant analysis (OPLS-DA) were applied to discriminate female and male flower buds. An apparent grouping trend (R2X, 0.809; Q2, 0.903) between female and male groups was exhibited with PCA and HCA. The two groups were also well discriminated with OPLS-DA (R2X, 0.808; R2Y, 0.976; Q2, 0.960). Combined with variable importance in projection (VIP) > 1.0 and p < 0.05 of OPLS-DA, it was found that the content of daucosterol, β-sitosterol, ursolic acid, and betulonic acid in male group was higher than that in female, which should be the key differences of chemical constituents in female and male flower buds of P. tomentosa. The study demonstrated that 1H NMR combined with multivariate statistics could be used to discriminate female and male plants and clarify differences, which provided a novel method to identify the gender of dioecious plants.

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Section: Discussionmentioning

confidence: 94%

“…The data were imported into the software and scaled by Pareto scaling method to reduce the relative importance of large values and to keep the data structure partially intact [34]. Then the data were submitted to PCA, HCA, and OPLS-DA analysis, respectively [35,36].…”

Section: Discussionmentioning

confidence: 99%

1H NMR Combined with Multivariate Statistics for Discrimination of Female and Male Flower Buds of Populus tomentosa

et al. 2021

Molecules

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“…[6][7][8][9][10] Among analytical methods employed on metabolomics studies, 11,12 the hydrogen nuclear magnetic resonance ( 1 H NMR) technique has been used to study metabolomes because it allows the detection and quantification of primary and secondary metabolites. 13 Recently, the 1 H NMR technique has been used for plant and fungus metabolome approach, such as the variation of metabolites involved in carbon metabolism of soybean plants infected by Sclerotinia sclerotiorum, 14 the effects of the flavonoids genistein, daidzein, apigenin, and kaempferol on mycotoxin citrinin production by Monascus purple-red molds, 15 the influence of environmental conditions on the metabolome of Solanum lycopersicum 16 and the chemical profile analysis of ten different Capsicum annuum cv. serrano plants cultivated in Mexico.…”

Section: Introductionmentioning

confidence: 99%

Metabolomics Analysis of C. lanceolatum Roots in the Presence of Its Endophytic Fungi

Serrano¹,

Lacerda²,

Moura³

et al. 2023

J. Braz. Chem. Soc.

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The aim of this work was to identify and quantify the metabolites present in the roots of Combretum lanceolatum inoculated with its endophytic fungi. The metabolomics was accomplished using the 1H nuclear magnetic resonance (NMR) spectral data and evaluated via rNMR software and Madison Metabolomics Consortium Database (MMCD). The principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) showed that plants inoculated with Trichoderma spirale (Ts) present differentiation and discrimination over the time as compared to control. Seven days after Ts fungal inoculation, 15 metabolites were identified at different concentrations comparing to the control plants. The plants inoculated with Ts fungus present the metabolites spermidine and pantothenate in higher concentrations and 3-hydroxybutyric acid and β-alanine in lower concentrations as compared to control plants, indicating any response to biotic stress. These metabolites are involved in various plant processes, including secondary metabolites biosynthesis, energy metabolism and self-defense. Therefore, this work demonstrates the diversification of primary metabolites composition influenced by endophytes inoculation.

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“…The concept of metabolomics was first proposed by Nicholson in 1999, as a component of systems biology. It extends the principles of genomics and transcriptomics, enabling qualitative and quantitative analysis of small molecular metabolites (<1500 Da) in biological systems [23,24].…”

Section: Introductionmentioning

confidence: 99%

Metabolomics Approaches for the Comprehensive Evaluation of Fermented Foods: A Review

Gao

Hou

Gao

et al. 2021

Foods

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Fermentation is an important process that can provide new flavors and nutritional and functional foods, to deal with changing consumer preferences. Fermented foods have complex chemical components that can modulate unique qualitative properties. Consequently, monitoring the small molecular metabolites in fermented food is critical to clarify its qualitative properties and help deliver personalized nutrition. In recent years, the application of metabolomics to nutrition research of fermented foods has expanded. In this review, we examine the application of metabolomics technologies in food, with a primary focus on the different analytical approaches suitable for food metabolomics and discuss the advantages and disadvantages of these approaches. In addition, we summarize emerging studies applying metabolomics in the comprehensive analysis of the flavor, nutrition, function, and safety of fermented foods, as well as emphasize the applicability of metabolomics in characterizing the qualitative properties of fermented foods.

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1H NMR-based metabolomic study of the effects of flavonoids on citrinin production by Monascus

Cited by 15 publications

References 39 publications

1H NMR Combined with Multivariate Statistics for Discrimination of Female and Male Flower Buds of Populus tomentosa

1H NMR Combined with Multivariate Statistics for Discrimination of Female and Male Flower Buds of Populus tomentosa

Metabolomics Analysis of C. lanceolatum Roots in the Presence of Its Endophytic Fungi

Metabolomics Approaches for the Comprehensive Evaluation of Fermented Foods: A Review

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