2011
DOI: 10.1039/c1sc00382h
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1H NMR metabolomics combined with gene expression analysis for the determination of major metabolic differences between subtypes of breast cell lines

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Cited by 19 publications
(18 citation statements)
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“…to all other investigated cell lines (Figure 8). In line with previous studies increased lactic acid levels resulting from more significant Warburg effect have been detected in ER negative compared to ER positive cells as well as negligible differences between cancer and normal cell lines [14].…”
Section: Endometabolite Analysissupporting
confidence: 75%
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“…to all other investigated cell lines (Figure 8). In line with previous studies increased lactic acid levels resulting from more significant Warburg effect have been detected in ER negative compared to ER positive cells as well as negligible differences between cancer and normal cell lines [14].…”
Section: Endometabolite Analysissupporting
confidence: 75%
“…Breast cancer cell lines have been investigated by application of liquid chromatography (LC)-MS [12], 2D-LC-MS [13] and nuclear magnetic resonance spectroscopy [14], before. Gas chromatography (GC) coupled to MS via electron ionization (EI) is a frequently used analytical technique for metabolite profiling [15][16][17] that allows metabolite annotation by application of mass spectral matching [18][19][20][21].…”
Section: Introductionmentioning
confidence: 99%
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“…7), has been associated with reduction of monolayer permeability to choline (9). A relationship between SCL44A and EGFR and choline metabolic profile has also been shown recently in metabolomics analysis of breast cancer cell lines (10). Furthermore, it should be kept in mind that EGFR mutation was identified as one of the major genetic differences between genomically determined GBM subtypes (8).…”
Section: Resultsmentioning
confidence: 99%
“…Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that binds to epidermal growth factor. Among its many functions, EGFR has been linked to the mechanism that reduces cell membrane permeability to choline (9,10). One of the most common oncogenic events observed in GBMs is the amplification and overexpression of EGFR kinase that occurs in 40 -60% of primary GBMs (11).…”
mentioning
confidence: 99%