2018
DOI: 10.1016/j.jstrokecerebrovasdis.2017.12.041
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2-(2-Benzofuranyl)-2-Imidazoline Mediates Neuroprotection by Regulating the Neurovascular Unit Integrity in a Rat Model of Focal Cerebral Ischemia

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Cited by 21 publications
(17 citation statements)
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“…The appropriate dose of 2-BFI exhibits protective properties against astrocyte damage in an ischemic stroke [35,36]. It was reported that 2-BFI can enhance the intercellular tight junction via the downregulation of MMP-9 expression levels, and suppress vascular endothelial permeability to preserve cerebral microvascular endothelial integrity [37,38]. Our previous studies demonstrated that 2-BFI reduced the disruption of the BBB and alleviated oxidative stress in the CNS of EAE mice [20].…”
Section: Eae Is Mediated By the Imbalance Of Lymphocytesmentioning
confidence: 97%
“…The appropriate dose of 2-BFI exhibits protective properties against astrocyte damage in an ischemic stroke [35,36]. It was reported that 2-BFI can enhance the intercellular tight junction via the downregulation of MMP-9 expression levels, and suppress vascular endothelial permeability to preserve cerebral microvascular endothelial integrity [37,38]. Our previous studies demonstrated that 2-BFI reduced the disruption of the BBB and alleviated oxidative stress in the CNS of EAE mice [20].…”
Section: Eae Is Mediated By the Imbalance Of Lymphocytesmentioning
confidence: 97%
“…Brains were removed and immersed in the same fixative for 24 h to make paraffin blocks. Brain tissues were sectioned into 5-µm thick slices, cortical sections were stained with hematoxylin-eosin as described (Zhang Z. et al, 2018), and stained slices were observed in a blinded fashion by a pathologist under a microscope (Olympus Optical, Tokyo, Japan). These pictures were used to verify model success and find the ischemic penumbra of the cortex.…”
Section: Histopathologymentioning
confidence: 99%
“…The brain was removed after perfusion, immersed in 4% paraformaldehyde for 24 h and fixed and sectioned into 5-µm slices. Sections were stained with hematoxylin and eosin (H&E) as previously described (Zhang et al, 2018b) and observed under a Bx51 light microscope (Olympus, Tokyo, Japan) at ×400 magnification. Nerve damage was assessed using the denatured cell index, which was calculated as the number of degenerated cells/total number of cells × 100%.…”
Section: Hematoxylin and Eosin Stainingmentioning
confidence: 99%
“…2-BFI attenuates excitotoxicity-mediated neuronal death and cerebral ischemia in vivo by inhibiting excessive calcium influx (Milhaud et al, 2000;Milhaud et al, 2002;Dong et al, 2008). We previously reported that 2-BFI can reduce endothelial cell damage, preserve cerebral vascular function, and mitigate BBB damage after acute ischemic stroke in vitro and in vivo (Tian et al, 2018;Zhang et al, 2018b). Studies show that this neuroprotective effect may be due to inhibition of apoptosis in endothelial and neuronal cells (Han et al, 2012).…”
Section: Introductionmentioning
confidence: 99%