2-(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(4-nitrophen­yl)-4-phenyl-1,3-diazabicyclo[3.1.0]hex-3-ene

Abstract

Abstract:As a consequence of one-pot, three-component reaction of trans-2-benzoyl-3-(4-nitrophenyl)aziridine with 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde and ammonium acetate, 2-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(4-nitrophenyl)-4-phenyl-1,3-diazabicyclo[3.1.0]hex-3-ene was achieved in good yield. The desired photochromic compound display interesting photochromic behavior in the crystalline and solution phase. The structure of the newly synthesized photochromic compound was characterized by elemental analysis, 1 H-NMR, 13 C-NMR and UV-Visible spectral data.

Domino Synthesis of Bis Phenyl Pyrazolone Piperidinium Salt Derivatives

“…Lactam structure is an active nucleus in pharmacological activity, [5] Pyrazolone is an active moiety as a pharmaceutical ingredient, especially in the class of non-steroidal anti-inflammatory agents used in the treatment of arthritis and other musculoskeletal and joint disorders. Pyrazolone derivatives were prepared and tested for a variety of biological activities such as antibacterial, [6][7] antidepressant, [8] anticonvulsant, [9][10] antifungal, [11] anticancer, [12] antiviral, [13] anti-inflammatory, [14][15] anti-HIV-1activities etc. [16] Many pyrazolones are known to be used as anti-proliferative agents, [17] protein kinase inhibitors, [18] herbicides, [19] central nervous system (CNS) depressants, [20] antiulcer, [21] antinociceptive [22] and immuno-suppressants.…”