2,5-dimethylcoumarins from leaves of Juniperus sabina

Pascual, Joaquín de; Feliciano, Arturo San; Corral, JoséM. Miguel del; Barrero, Alejandro F.; Rubio, M.E. Ocete; Muriel, Livio

doi:10.1016/0031-9422(81)85289-2

Cited by 17 publications

(9 citation statements)

References 6 publications

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“…Faiella et al (2014) identified 19,20 (7-demethyl-8-methoxycoumarsabin and 8-methoxycoumarsabin, respectively) from Sideritis pullulans. The latter had also been identified as a constituent of Leucas inflata roots (Al Yousuf et al, 1999) and of Juniperus sabina (De Pascual et al, 1981); it has also been synthesised (Ahluwalia & Mukherjee, 1984).…”

Section: Compounds 14-21mentioning

confidence: 99%

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

et al. 2020

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Section: Compounds 14-21mentioning

confidence: 99%

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

et al. 2020

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“…The previously undescribed 3,5-dimethyl substitution pattern is present in coumarsabin (468) and 8-methoxycoumarsabin (469) from Juniperus sabina leaves. 384…”

Section: E U P a T O R I O D E ~ ~~~mentioning

confidence: 99%

Coumarins

Murray¹

1989

Nat. Prod. Rep.

122

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“…Natural products, as crude plant extracts, have been used for thousands of years, and many of these ancient formulations have been recorded in ancient literature. 1 There is over 4000 years of recorded history of botanical medicines from China, the Middle East, South America, Europe, and Mexico. The first available records, dated from about 2600 B.C., were found from Mesopotamian clay tablets (from modern day Iraq, Iran, and part of Syria) written in cuneiform that contained approximately 1000 different plant-derived formulations.…”

Section: Introductionmentioning

confidence: 99%

An Analysis of Cytotoxic Botanical Formulations Used in the Traditional Medicine of Ancient Persia as Abortifacients

Madari

Jacobs

2004

J. Nat. Prod.

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We report here an analysis of plants used by traditional healers of ancient Persia to induce abortions. Six herbal formulations that contain 39 different species from 21 plant families with their vernacular names, English names, amounts used, and their methods of preparation are reported. Our initial objective of this ethnobotanical analysis was to evaluate the validity and the efficacy of the plants used by (1) comparing other reported uses of these plants in traditional medicine, (2) investigating the medical and pharmacological literature on the medicinal properties of the plant species used, and (3) investigating the reported cytotoxic effects of compounds prevalent in these plants. Previous phytochemical analyses have shown that a number of plant species are rich in coumarin compounds that have potential antineoplastic or cytotoxic activities. Our results indicate a correlation between the reported use of these plants as abortifacients and their cytotoxic (antineoplastic) effects. In addition, we discuss the process in which this ethnobotanical investigation led to the discovery of dicoumarol (a coumarin anticoagulant) as a potential chemotherapeutic agent.

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2,5-dimethylcoumarins from leaves of Juniperus sabina

Cited by 17 publications

References 6 publications

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Coumarins

An Analysis of Cytotoxic Botanical Formulations Used in the Traditional Medicine of Ancient Persia as Abortifacients

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