2.5% v 10% Phenylephrine in Maintaining Mydriasis During Cataract Surgery

The influence of iris color on the pupillary light reflex

“…As known in Horner's disease, evidence suggests that melanin content of some melanocytes is subject to adrenergic regulation. In pharmacological trials, direct adrenergic agents such as adrenaline (epinephrine) [13] or alpha-adrenergic agents [16] are more efficient in eyes with blue irides, as well as indirect adrenergics such as hydroxyamphetamine (paredrine) [8] or both direct and indirect adrenergics such as phenylephrine (neosynephrine) [6]. In conclusion, the greater short-term movement of brown irides in the present study may be based on a different number/sensitivity of adrenergic receptors compared to blue irides and/or be influenced by melanin.…”

Mydriatic insert and intracameral injections compared with mydriatic eyedrops in cataract surgery: Controlled studies

“…However, their limitations have prompted the search for alternative methods. Many approaches have been tested during the past 30 years, including topical viscous phenylephrine or intraoperative epinephrine (called adrenalin in some countries), [19][20][21][22] preoperative diclofenac 23 or atropine 1.0%, 24 and cellulose sponges soaked in mydriatic agents. 3,25 Review Purpose and Method…”

Intracameral Mydriatics in Cataract Surgery

“…(Ogut, Bozkurt et al 1996;Elibol, Alcelik et al 1997), Third, even if a good mydriasis is achieved initially, the mydriatic effect often tends to diminish during the operation, and especially when the procedure takes longer than expected. Different solutions have been suggested to prolong the mydriatic effect from topical mydriatics such as preoperative treatment with diclofenac (Antcliff and Trew 1997), viscous 10% phenylephrine, (Duffin, Pettit et al 1983) or intraoperative intracameral epinephrine. (Duffin, Pettit et al 1983;Liou and Yang 1998).…”

“…Different solutions have been suggested to prolong the mydriatic effect from topical mydriatics such as preoperative treatment with diclofenac (Antcliff and Trew 1997), viscous 10% phenylephrine, (Duffin, Pettit et al 1983) or intraoperative intracameral epinephrine. (Duffin, Pettit et al 1983;Liou and Yang 1998). In 2003, we first introduced the concept of intracamerally injected mydriatics, in which mydriatic substances were mixed with the intracameral lidocaine given at the start of the phacoemulsification cataract procedure.…”