2-Alkyloxyalkylthiohypoxanthines as new potent inhibitors of xanthine oxidase

Synthesis and evaluation of 1-alkyl-4-phenyl-[1,2,3]-triazole derivatives as antimycobacterial agent

“…In particular, when the reaction occurs between alkyl or aryl azides and terminal acetylenes, [1,2,3]-triazoles are obtained. [9][10][11][12][13][14][15][16][17][18][19][20][21] If the cycloaddition is thermally conduced, a 1:1 mixture of the 1,4 and 1,5-regioisomers of triazole is usually obtained. Various attempts to control the regioselectivity without much success were reported until the discovery of the copper(I)-catalyzed reaction in 2002, which exclusively yields the 1,4-disubstituted-[1,2,3]-triazole.…”

“…9,10 The 4-aryl-[1,2,3]-triazoles were discovered to be a unique template for the inhibition of the metalloprotease MetAP2. 11 In the literature triazoles are described as antiplatelet agents, 12 dopamine D2 receptor ligands (related to Schizophrenia 13 ) anti-inflammatory, 14,15 and antimicrobial agents. [16][17][18] Based on the rationale above, the purpose of this study was to synthesize several 4-phenyl-[1,2,3]-triazole derivatives with small molar mass and test them for inhibition of the growth of M. tuberculosis H37Rv strain (ATCC 27294).…”

Design, synthesis and evaluation of 2,4-diarylpyrano[3,2-c]chromen-5(4H)-one as a new class of non-purine xanthine oxidase inhibitors

“…Therefore, the selective inhibition of XO may result in broad spectrum chemotherapeutic for gout, cancer, inflammation and oxidative damage [2][3][4] . Allopurinol 3,4 , 2-alkyl hypoxanthines 5,6 , pterin and 6-formylpterin 7 represents the class of purine-based xanthine oxidase inhibitors. All these inhibitors have been successfully utilized and have proved their inhibitory potential towards the enzyme.…”

A QSAR Study for Modeling of 8-Azaadenine Analogues Proposed as A1 Adenosine Receptor Antagonists Using Genetic Algorithm Coupling Adaptive Neuro-Fuzzy Inference System (ANFIS)

“…Some of these compounds were shown to be very effective, because their affinity (Ki values) was found in the range of nanomolar units. [30][31][32][33][34][35][36][37][38] A number of models of QSAR have been developed about the QSAR modeling of A adenosine receptors.…”