2-Amino-6-mercapto-6-phenyl-5,6-dihydro-1,3,4-thiadiazines

Thiosemicarbazides in heterocyclization

“…Finding new methodologies for the synthesis of a family of biologically potent compounds by using building blocks with multifunctional groups is a key issue for drug discovery. Thiosemicarbazides appear to be ideal candidates for the development of such processes, as they are the core feature in families of compounds known to display biological activities, e.g ., pyrazoles [1], 1,2,4‐triazoles [1–5], 1,3,4‐oxadiazoles [3, 4], 1,3,4‐thiadiazoles [1, 4, 5], 1,3‐thiazoles [6], 1,2,4‐triazepine [7], 1,3,4‐thiadiazine [8], and 1,3,4‐thiadiazepine [9].…”

Synthesis of Spiro(indenepyrazole) and Indenotriazinone Derivatives from 4-substituted Thiosemicarbazides and (1,3-dioxo-2,3-dihydro-1H-Inden-2-Ylidene)Propanedinitrile

“…[1][2][3][4][5][6] Thiosemicarbazides 1 appear to be ideal candidates for the development of such processes, since they are the core feature in families of compounds known to display biological activities, e.g. pyrazoles, 7 1,2,4-triazoles, 7-9 1,3,4-oxadiazoles, 8 1,3,4-thiadiazoles, 7 1,3-thiazoles, 10 1,2,4-triazepines, 11 1,3,4thiadiazines 12 and 1,3,4-thiadiazepines. 13 Four-, five-, six-and seven-membered heterocyclic compounds were prepared by reaction of thiosemicarbazide derivatives with α-and β-haloketones.…”