2-deoxy-d-glucose Ameliorates Animal Models of Dermatitis

Choi, Soo Young; Lee, Chanmi; Choi, Youngkeun; An, In‐Sook; Bae, Seunghee; An, Sungkwan; Jung, Jin Hyuk

doi:10.3390/biomedicines8020020

Cited by 21 publications

(22 citation statements)

References 52 publications

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“…Basal respiration, ATP-linked respiration, maximal respiration and reserve capacity were also significantly higher in the psoriatic DMSCs. Choi et al ( 23 ) reported that ablation of Glut1 attenuates animal models of psoriasis. HK2 is critically important for aerobic glycolysis ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Dysregulated Dermal Mesenchymal Stem Cell Proliferation and Differentiation Interfered by Glucose Metabolism in Psoriasis

Zhao

Xing

et al. 2021

IJSC

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Background and Objectives Psoriasis is a chronic inflammatory skin disease, which the mechanisms behind its initiation and development are related to many factors. DMSCs (dermal mesenchymal stem cells) represent an important member of the skin microenvironment and play an important role in the surrounding environment and in neighbouring cells, but they are also affected by the microenvironment. We studied the glucose metabolism of DMSCs in psoriasis patients and a control group to reveal the relationship among glucose metabolism, cell proliferation activity，and VEC (vascular endothelial cell) differentiation in vitro , we demonstrated the biological activity and molecular mechanisms of DMSCs in psoriasis. Methods and Results We found that the OCR of DMSCs in psoriatic lesions was higher than that in the control group, and mRNA of GLUT1 and HK2 were up-regulated compared with the control group. The proliferative activity of DMSCs in psoriasis was reduced at an early stage, and mRNA involved in proliferation, JUNB and FOS were expressed at lower levels than those in the control group. The number of blood vessels in psoriatic lesions was significantly higher than that in the control group (p<0.05), which the mRNA of VEC differentiation, CXCL12, CXCR7, HEYL and RGS5 tended to be increased in psoriatic lesions compared to the control group, in addition to Notch3. Conclusions We speculated that DMSCs affected local psoriatic blood vessels through glucose metabolism, and the differentiation of VECs, which resulted in the pathophysiological process of psoriasis.

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Section: Discussionmentioning

confidence: 99%

Dysregulated Dermal Mesenchymal Stem Cell Proliferation and Differentiation Interfered by Glucose Metabolism in Psoriasis

Zhao

Xing

et al. 2021

IJSC

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“…28 2-DG is known to exert anti-inflammatory effects. 29 2-DG suppressed immune cell activation and reduced disease severity in an autoimmune model of rheumatoid arthritis. 30 Although there exists several possible therapeutic indications for 2-DG, there is no approved indication for 2-DG as a therapeutic agent so far.…”

Section: Diagnostics and Therapeutics Applicationsmentioning

confidence: 93%

2-Deoxy-d-glucose: from diagnostics to therapeutics

Goel

2021

Int J Basic Clin Pharmacol

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Glucose is the most common source of cellular energy and a substrate for many biochemical processes. Abnormal glucose signalling has been found in many diseases including cancers and inflammatory diseases. A glucose analog, 2-deoxy-D-glucose (2DG) which interferes with the cellular glucose metabolism has shown promising results both as a diagnostic and therapeutic agent in certain diseased conditions such as cancer, cardiovascular diseases, Alzheimer disease, etc. More recently, Viral-infected cells have also been found to increase their glucose uptake and recently Drug Controller General of India (DCGI) has given approval for the therapeutic use of 2DG in managing severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infection which has received worldwide attention and has been declared a public health emergency of global concern. An attempt has accordingly been made in this article to review the diagnostic and therapeutic potentials of 2-deoxy-glucose with special emphasis on to its implications in SARS-CoV-2.

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“…Recently, 2 deoxy glucose (2DG), an anticancer drug, has been approved for emergency use in India as an adjunct therapy to treat COVID-19. 2DG inhibits host glycolytic pathway, anti-inflammatory action and interacts with viral proteins (161,162). An exhaustive list of repurposed drugs targeting various stages of virus life cycle and their current status of clinical trials has been listed in Almasi and Mohammadipanah (163).…”

Section: Disease Management Of Covid-19: Potential Treatment Options and Repurposing The Existing Drugs For Covid-19 Treatmentmentioning

confidence: 99%

The Omic Insights on Unfolding Saga of COVID-19

et al. 2021

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The year 2019 has seen an emergence of the novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease of 2019 (COVID-19). Since the onset of the pandemic, biological and interdisciplinary research is being carried out across the world at a rapid pace to beat the pandemic. There is an increased need to comprehensively understand various aspects of the virus from detection to treatment options including drugs and vaccines for effective global management of the disease. In this review, we summarize the salient findings pertaining to SARS-CoV-2 biology, including symptoms, hosts, epidemiology, SARS-CoV-2 genome, and its emerging variants, viral diagnostics, host-pathogen interactions, alternative antiviral strategies and application of machine learning heuristics and artificial intelligence for effective management of COVID-19 and future pandemics.

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2-deoxy-d-glucose Ameliorates Animal Models of Dermatitis

Cited by 21 publications

References 52 publications

Dysregulated Dermal Mesenchymal Stem Cell Proliferation and Differentiation Interfered by Glucose Metabolism in Psoriasis

Dysregulated Dermal Mesenchymal Stem Cell Proliferation and Differentiation Interfered by Glucose Metabolism in Psoriasis

2-Deoxy-d-glucose: from diagnostics to therapeutics

The Omic Insights on Unfolding Saga of COVID-19

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