2-¹⁸F-Fluoroacetate: A Useful Tool for Assessing Gliosis in the Central Nervous System?

Evaluation of 2-[18F]fluoroacetate Kinetics in Rodent Models of Cerebral Hypoxia–Ischemia

“…]fluoroacetate was suggested to be a potentially useful PET tracer of glial metabolism in the central nervous system and the need for further validation-including evaluation of the [ 18 F]FACE kinetics-was emphasized. 19,20 These results suggested the intriguing possibility that the observed [ 18 F]FACE uptake is metabolism-driven, thus suggesting the potential use of this tracer for imaging glia-specific metabolism in these animal models. In this study, we have investigated the extent to which [ 18 F]FACE uptake in cerebral H-I is driven by metabolism or by other factors.…”

“…14 In the past, this mechanism has been exploited by the use of sodium fluoroacetate as a potent rodenticide and also for the study of brain metabolism. 15,16 The use of [ 18 19,20 These results suggested the intriguing possibility that the observed [ 18 F]FACE uptake is metabolism-driven, thus suggesting the potential use of this tracer for imaging glia-specific metabolism in these animal models. In this study, we have investigated the extent to which [ 18 F]FACE uptake in cerebral H-I is driven by metabolism or by other factors.…”

PET Imaging of Gliomas

“…Acetyl-CoA is a substrate for several biochemical pathways, most notably the tricarboxylic acid (TCA) cycle, and for glutamine and lipid synthesis. Additional studies have demonstrated that the preferential use of acetate by astrocytes is mediated by transport, although the exact mechanism is not fully understood (Lopresti and Mason 2009). In a clinical study, Yamamoto et al (2008) F]FDG in high-grade gliomas were significantly higher than those in lowgrade gliomas while no significant differences were observed with [ 11 C]MET.…”

“…Acetate is transported into the cell via the monocarboxylic acid transporter where it is converted in mitochondria to acetyl-coenzyme A (acetyl-CoA) (Lopresti and Mason 2009). Acetyl-CoA is a substrate for several biochemical pathways, most notably the tricarboxylic acid (TCA) cycle, and for glutamine and lipid synthesis.…”

Fluorinase mediated chemoenzymatic synthesis of [18F]-fluoroacetate

“…There has been a recent interest and discussion on the role for [ 18 F]-fluoroacetate in PET imaging, particularly as an alternative to [ 11 C]-acetate. 10,11 For example a comparison of [ 18 F]-fluoroacetate with [ 11 C]-acetate in prostate tumour bearing mice showed a 5-fold higher tumour uptake of the fluorinated tracer. 11 In 2009 [ 18 F]-fluoroacetate was evaluated in sarcoma, inflammation, glioblastoma, stroke and ischemiahypoxia mice models.…”