20(S)-Ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway

Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage

“…2, B and C) after treatment with BaP. Much evidence has already shown that 20(S)-Rg3 has anticarcinogenic (Yun et al, 2001) and antiapoptotic activity (Min et al, 2006). Our present results indicate that only 20(S)-Rg3 can possess a major cytoprotective effect toward DNA damage and cell death.…”

Molecular docking studies of anti-apoptotic BCL-2, BCL-XL, and MCL-1 proteins with ginsenosides from Panax ginseng

“…Toxicological and clinical studies support the production and consumption of ginseng, which has been shown to reduce cancer risk by up to 50% 38 . Previous investigations have shown that ginsenosides Rg3 inhibit the endothelial cell apoptosis through increased expression of BAX and decreased BCL-2 in prostate cancer cells 39,40 . Ginsenoside Rh2 induces apoptosis and interacts with anti-apoptotic proteins in rat glioma C6Bu-1 cells 41 as well as inhibits the growth of human ovarian cancer cells in nude mice 42 .…”

A novel homospermidine conjugate inhibits growth and induces apoptosis in human hepatoma cells

“…Briefly, the cell lysate (50 mg of protein) was added into the buffer containing 150 mol/L Ac-DEVD-pNA, Ac-IETD-pNA, and Ac-LEHD-pNA to a final volume of 150 µL. The reaction mixture was incubated at 37 °C for 1 h. The absorbance of enzymatically-released pNA was measured at 405 nm on a microplate reader every 20 min [13] .…”