2010 Consensus Statement on the Worldwide Standardization of the Hemoglobin A1c Measurement

Hanås, Ragnar; John, Garry

doi:10.1111/j.1399-5448.2010.00690.x

Cited by 55 publications

(57 citation statements)

References 10 publications

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“…On the other hand, there was no significant difference between the nondiabetic and the short-term T1D groups in the frequency of sensor values in the hypoglycemic range, which is particularly striking. In contrast, participants in the longer-term T1D group achieved A1C levels near or within the <7.5% pediatric target range (9) at the expense of a sharp increase in exposure to biochemical hypoglycemia. Using a one-step hyperinsulinemic, hypoglycemic clamp, we have demonstrated that 56% of the subjects in the short-term group maintained a glucagon response to hypoglycemia, which may have contributed to their low incidence of biochemical hypoglycemia (10).…”

Section: Discussionmentioning

confidence: 98%

Achievement of Target A1C Levels With Negligible Hypoglycemia and Low Glucose Variability in Youth With Short-Term Type 1 Diabetes and Residual β-Cell Function

et al. 2012

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OBJECTIVETo determine exposure to hyper- and hypoglycemia using blinded continuous glucose monitoring (CGM) profiles in youth with type 1 diabetes (T1D) with residual β-cell function during the first year of insulin treatment.RESEARCH DESIGN AND METHODSBlinded, 3–7 day CGM profiles were obtained in 16 short-term T1D patients (age 8–18 years, T1D duration 6–52 weeks) who had peak C-peptide levels ranging from 0.46 to 1.96 nmol/L during a mixed-meal tolerance test. Results in this short-term group were compared with those in 34 patients with well-controlled, longer-term T1D (duration ≥5 years), matched for age and A1C with the short-term T1D group, and with those in 26 age-matched nondiabetic individuals.RESULTSDespite matching for A1C, and therefore similar mean sensor glucose levels in the two T1D groups, short-term T1D participants had a lower frequency of hypoglycemia (0.3 vs. 7.6%, P < 0.001), a trend toward less hyperglycemia (17 vs. 32%, P = 0.15), and a greater percentage in the target range (median 77 vs. 60%, P = 0.02). Indeed, the percentage of sensor glucose levels ≤70 mg/dL in the short-term T1D group (0.3%) did not differ from those in the nondiabetic group (1.7%, P = 0.73). The coefficient of variation of sensor glucose levels (an index of glucose variability) was lower in short-term vs. longer-term T1D participants (27 vs. 42%, respectively, P < 0.001).CONCLUSIONSIn youth with short-term T1D who retain residual β-cell function, there is negligible exposure to hypoglycemia and lower glucose variability than in youth with well-controlled T1D of longer duration.

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Section: Discussionmentioning

confidence: 98%

Achievement of Target A1C Levels With Negligible Hypoglycemia and Low Glucose Variability in Youth With Short-Term Type 1 Diabetes and Residual β-Cell Function

et al. 2012

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“…Data on HbA1c are derived from capillary blood samples taken in connection with visits to the diabetes center. The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) reference method is used in Sweden, and HbA1c values are presented both as IFCC (mmol/mol) and as NGSP/DCCT (%) …”

Section: Methodsmentioning

confidence: 99%

Poor metabolic control in childhood strongly correlates to diabetes‐related premature death in persons <30 years of age—A population‐based cohort study

Samuelsson

Hanberger

et al. 2020

Pediatr Diabetes

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Background/objective: The importance of metabolic control in childhood regarding excess risk of death in young persons has not been well studied. This registry-based study aimed to investigate mortality rates and cause of death related to metabolic control in young persons (≤29 years) in Sweden with type 1 diabetes.Methods: All 12 652 subjects registered in the Swedish pediatric diabetes quality register, from 2006 to 2014, were included. Data were merged with the Swedish Cause of Death Register. Standardized mortality rates were calculated using the official Swedish population register.Results: Of 68 deaths identified, 38.2% of the deaths were registered as being due to diabetes whereof the major cause of death was acute complications. Overall standardized mortality ratio was 2.7 (2.1-3.4, 95% CI). Subjects who died from diabetes had a mean HbA1c of 74 ± 19 mmol/mol (8.9 ± 1.7%) during childhood vs 62 ± 12 mmol/mol (7.8 ± 1.1%) in those still alive (P < .001). Conclusions:In this nationwide cohort of young subjects with type 1 diabetes, there was a high mortality rate compared to the general population. Mean HbA1c in childhood was significantly higher in those who died from diabetes, compared to subjects who were still alive.To decrease mortality in young persons with type 1 diabetes it is essential not only to achieve but also to maintain a good metabolic control during childhood and adolescence.

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“…In NDR all available values were used for the mean HbA1c value. The IFCC reference method has been adopted in Sweden, and HbA1c values will be presented both as NGSP/DCCT (%) and as IFCC (mmol/mol). For example, 58 mmol/mol (IFFC) corresponds to 7.5% (NGSP/DCCT), 10 mmol/mol is about 0.9%.…”

Section: Methodsmentioning

confidence: 99%

A high mean-HbA1c value 3-15 months after diagnosis of type 1 diabetes in childhood is related to metabolic control, macroalbuminuria, and retinopathy in early adulthood-a pilot study using two nation-wide population based quality registries

2013

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2010 Consensus Statement on the Worldwide Standardization of the Hemoglobin A1c Measurement

Abstract: Hanas R. and John G. 2010 Consensus Statement on the Worldwide Standardization of the Hemoglobin A1c Measurement.

Cited by 55 publications

References 10 publications

Achievement of Target A1C Levels With Negligible Hypoglycemia and Low Glucose Variability in Youth With Short-Term Type 1 Diabetes and Residual β-Cell Function

Achievement of Target A1C Levels With Negligible Hypoglycemia and Low Glucose Variability in Youth With Short-Term Type 1 Diabetes and Residual β-Cell Function

Poor metabolic control in childhood strongly correlates to diabetes‐related premature death in persons <30 years of age—A population‐based cohort study

A high mean-HbA1c value 3-15 months after diagnosis of type 1 diabetes in childhood is related to metabolic control, macroalbuminuria, and retinopathy in early adulthood-a pilot study using two nation-wide population based quality registries

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