2011–2021 rising prevalence of HPV infection among oropharyngeal carcinoma in France

Gorphe, Philippe; Blanchard, Pierre; Garcia, Gabriel; Classe, Marion; Even, Caroline; Temam, Stéphane; Breuskin, Ingrid

doi:10.1186/s12885-022-10091-8

Cited by 7 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nonetheless, the overall increase in the incidence of oropharyngeal tumors observed in the last decades in our country [27,28] suggests that there is a real increase in the incidence of HPV-driven lesions. These results are consistent with recent trends observed in other European geographical areas including the Netherlands, France, Denmark, Sweden, and Southern Europe [2,[29][30][31][32][33][34][35], with the growing prevalence of oral HPV infection due to changes in sexual habits likely being responsible for the observed epidemiological trends in oropharyngeal cancer [36].…”

Section: Discussionsupporting

confidence: 90%

Rising Trend in the Prevalence of HPV-Driven Oropharyngeal Squamous Cell Carcinoma during 2000–2022 in Northeastern Italy: Implication for Using p16INK4a as a Surrogate Marker for HPV-Driven Carcinogenesis

Boscolo‐Rizzo

Polesel

Mistro

et al. 2023

Cancers

View full text Add to dashboard Cite

Background: The prevalence and incidence of oropharyngeal squamous cell carcinomas (OPSCCs) driven by human papillomavirus (HPV) infection are increasing worldwide, being higher in high-income countries. However, data from Italy are scanty. p16INK4a overexpression is the standard in determining HPV-driven carcinogenesis, but disease prevalence impacts on its positive predictive value. Methods: This is a multicenter retrospective study enrolling 390 consecutive patients aged ≥18 years, diagnosed with pathologically confirmed OPSCC in Northeastern Italy between 2000 and 2022. High-risk HPV-DNA and p16INK4a status were retrieved from medical records or evaluated in formalin-fixed paraffin-embedded specimens. A tumor was defined as HPV-driven when double positive for high-risk HPV-DNA and p16INK4a overexpression. Results: Overall, 125 cases (32%) were HPV-driven, with a significant upward temporal trend from 12% in 2000–2006 to 50% in 2019–2022. The prevalence of HPV-driven cancer of the tonsil and base of the tongue increased up to 59%, whereas it remained below 10% in other subsites. Consequently, the p16INK4a positive predictive value was 89% for the former and 29% for the latter. Conclusions: The prevalence of HPV-driven OPSCC continued to increase, even in the most recent period. When using p16INK4a overexpression as a surrogate marker of transforming HPV infection, each institution should consider the subsite-specific prevalence rates of HPV-driven OPSCC as these significantly impact on its positive predictive value.

show abstract

Section: Discussionsupporting

confidence: 90%

Rising Trend in the Prevalence of HPV-Driven Oropharyngeal Squamous Cell Carcinoma during 2000–2022 in Northeastern Italy: Implication for Using p16INK4a as a Surrogate Marker for HPV-Driven Carcinogenesis

Boscolo‐Rizzo

Polesel

Mistro

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

“…In the United States, the incidence of HPV-positive OPC has increased by 225% among young men in the last two decades [ 9 ]. In Europe, a similar trend has been observed, with incidence rates of HPV-positive OPC increasing by approximately 60% among young men in the last 10 years [ 10 ].…”

Section: Introductionsupporting

confidence: 62%

Biplex quantitative PCR to detect transcriptionally active human papillomavirus 16 from patient saliva

Deutsch,

Sais,

Keatinge

et al. 2024

BMC Cancer

View full text Add to dashboard Cite

Head and neck cancers, particularly oropharyngeal cancers (OPC), have been increasingly associated with human papillomavirus (HPV) infections, specifically HPV16. The current methods for HPV16 detection primarily rely on p16 staining or PCR techniques. However, it is important to note the limitations of conventional PCR, as the presence of viral DNA does not always indicate an ongoing viral infection. Moreover, these tests heavily rely on the availability of tissue samples, which can present challenges in certain situations. In this study, we developed a RT-qPCR biplex approach to detect HPV16 oncogenes E6 and E7 RNA in saliva samples from OPC patients. Salivary supernatant was used as the liquid biopsy source. We successfully obtained RNA from salivary supernatant, preserving its integrity as indicated by the detection of several housekeeping genes. Our biplex approach accurately detected E6 and E7 RNA in HPV16-positive cell lines, tissues, and finally in OPC salivary samples. Importantly, the assay specifically targeted HPV16 and not HPV18. This biplexing technique allowed for reduced sample input without compromising specificity. In summary, our approach demonstrates the potential to detect viable HPV16 in saliva from OPC patients. Since the assay measures HPV16 RNA, it provides insights into the transcriptional activity of the virus. This could guide clinical decision-making and treatment planning for individuals with HPV-related OPC.

show abstract

“…Higher prevalence of oral HPV among older adults has been previously reported and may be due to increased HPV exposure, infection and/or persistence with age, potential loss of immune control, and/or reactivation of latent HPV infections . Recent studies have also reported that median age at diagnosis for HPV-related OPC is increasing, and that among patients 65 years and older, the proportion of HPV-related OPC increased from 41% during 1995 to 2000 to 75% during 2007 to 2013 . Reasons behind this trend are not fully understood, but it is therefore not surprising to observe an increased prevalence of oral HPV infection in middle-aged and older men, as HPV predates OPC occurrence.…”

Section: Discussionmentioning

confidence: 98%

Oral Human Papillomavirus Prevalence and Genotyping Among a Healthy Adult Population in the US

Giuliano

Felsher

Waterboer

et al. 2023

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

ImportanceIn the US, oropharyngeal cancer, predominantly caused by high-risk (HR) human papillomavirus (HPV) infection, is the most frequent HPV-associated cancer, surpassing cervical cancer. However, little is known about oral HPV prevalence and genotype distribution in the general population.ObjectiveTo assess oral HPV prevalence and factors associated with HR and low-risk infection in a general US population.Design, Setting, and ParticipantsPROGRESS (Prevalence of Oral HPV Infection, a Global Assessment) was a cross-sectional observational study conducted between November 2021 and March 2022 in 43 dental offices in the US (24 urban, 13 urban cluster, and 6 rural sites), spanning 21 states. Eligible participants were aged 18 to 60 years, visiting dental clinics for routine dental examination. Dental clinics used targeted sampling to recruit equal distributions of men and women and across age groups.ExposureParticipants provided an oral gargle specimen for HPV DNA and genotyping and completed behavioral questionnaires, and dentists reported oral health status. Detection of HPV DNA and genotyping was performed using the SPF10/DEIA/LiPA25 system at a central laboratory.Main OutcomeOral HPV prevalence.ResultsOf the 3196 participants enrolled, mean (SD) age was 39.6 (12.1) years, and 55.5% were women. Oral HPV prevalence was 6.6% (95% CI, 5.7%-7.4%) for any HPV genotype, and 2.0% (95% CI, 1.5%-2.5%), 0.7% (95% CI, 0.4%-1.0%), and 1.5% (95% CI, 1.1%-1.9%) for HR, HPV-16, and 9-valent-HPV vaccine types, respectively. Among HPV-positive participants, HPV-16 was the most prevalent genotype (12.4% among men and 8.6% among women). Prevalence of HPV was higher in men than women and highest among men aged 51 to 60 years (16.8%, 6.8%, and 2.1% for any HPV, HR HPV, and HPV-16, respectively). Factors associated with HR oral infection included being male (adjusted odds ratio [AOR], 3.1; 95% CI, 1.2-8.5), being aged 51 to 60 years (AOR, 3.3; 95% CI, 1.5-7.3), having 26 or more lifetime male sex partners (AOR, 6.5; 95% CI, 2.3-18.7), and having 6 to 25 lifetime female oral sex partners (AOR, 3.4; 95% CI, 1.3-8.7).Conclusions and RelevanceIn this cross-sectional study, oral HPV burden was highest among older men who may be at higher risk of developing oropharyngeal cancer. In addition to male sex and older age, HR oral HPV infection was also associated with sexual behaviors, including increasing number of male sex partners and female oral sex partners.

show abstract

2011–2021 rising prevalence of HPV infection among oropharyngeal carcinoma in France

Cited by 7 publications

References 32 publications

Rising Trend in the Prevalence of HPV-Driven Oropharyngeal Squamous Cell Carcinoma during 2000–2022 in Northeastern Italy: Implication for Using p16INK4a as a Surrogate Marker for HPV-Driven Carcinogenesis

Rising Trend in the Prevalence of HPV-Driven Oropharyngeal Squamous Cell Carcinoma during 2000–2022 in Northeastern Italy: Implication for Using p16INK4a as a Surrogate Marker for HPV-Driven Carcinogenesis

Biplex quantitative PCR to detect transcriptionally active human papillomavirus 16 from patient saliva

Oral Human Papillomavirus Prevalence and Genotyping Among a Healthy Adult Population in the US

Contact Info

Product

Resources

About