BackgroundIt is known that anti-TNF therapy is given to patients with persistently high disease activity despite conventional treatments according to the ASAS recommendations (1). Although biopsychosocial symptoms were well known, biopsychosocial assessments are insufficient in the literature.ObjectivesThe aim of this study was to compare the biopsychosocial status between patients with AS who were decided to be treated with anti-TNF treatment and patients with AS who did not receive any anti-TNF treatment. Also, it was aimed to investigate the effectiveness of 3 months anti-TNF treatment on biopsychosocial status.Methods74 AS patients who are decided to receive anti-TNF treatment and 38 AS patients, who didn’t, were included in the study. Socio-demographic informations of patients were collected. The mean age of the patients (n = 112) was 41,9±19,8 years. Health Assessment Questionnaire (HAQ) was used to assess functional status and daily living activities. The Hospital Anxiety and Depression Scale (HADS) was used to assess anxiety and depression levels. Biopsychosocial status of the patients was evaluated by the BETY-Biopsychosocial Questionnaire (BETY-BQ) (2,3). The same evaluations were repeated after 3 months in 36 patients using anti-TNF.ResultsA statistically significant difference was observed in BETY-BQ, HADS anxiety and HAQ scores, when the groups were compared. There was no statistically significant difference in HADS depression scores (Table 1). The difference after 3 months of anti-TNF treatment was significant in all parameters (Table 2).FRI0713HPR Table 1 Difference between the patients who decided to receive anti-TNF and who did not.
Anti-TNF Decided Group (n=74)
Non-receiving Anti-TNF Group
(n=38)
p-value*
HAQ14,33±10,15,46±10,7
,000
HADS - Anxiety10,24±5,07,58±5,0
,011
HADS - Depression8,38±4,36,45±4,3,053BETY-BQ59,32±24,146,74±25,8
,032
*Mann-Whitney UFRI0713HPR Table 2 First and ‘After 3 months’ measurements in patients who received anti-TNF treatment.
N=36
1st measurement
‘After 3 months’ measurement
p-value*
HAQ14,99±11,15,36±10,6
,000
HADS - Anxiety10,33±5,37,72±4,7
,001
HADS - Depression8,89±4,75,78±4,7
,000
BETY-BQ59,33±25,144,28±23,2
,000
* Wilcoxon TestConclusionIt was observed that the patients who were decided to be received anti-TNF treatment had worse functionality, anxiety, and biopsychosocial status than the patients who did not receive anti-TNF treatment. Anti-TNF treatment was found to be effective in three months period in terms of these biopsychosocial symptoms that the patients had.References[1] Braun Jv, Van Den Berg R, Baraliakos X, Boehm H, Burgos-Vargas R, Collantes-Estevez E, et al. 2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. Annals of the rheumatic diseases. 2011;70(6):896-904.[2] Ünal E, Arin G, Karaca Nb, Kiraz S, Akdoğan A, Kalyoncu U, et al. Romatizmalı hastalar için bir yaşam kalitesi ölçeğinin geliştirilmesi: madde havuzunun oluşturulması. Journal of Exercise Therapy and Rehabilitation. 2017;4(2):67-75.[3] Kisa...