2022 American Society of Clinical Oncology (ASCO): Meeting highlights

Black, Peter C.; Fallah-Rad, Nazanin; Loblaw, Andrew; Kassouf, Elie; Keyes, Mira; Basappa, Naveen S.; Swaminath, Anand

doi:10.5489/cuaj.8097

Cited by 1 publication

(1 citation statement)

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“…After completing treatment, children diagnosed with brain stem glioma requires lifelong follow-up care. 19 Our follow-up protocol involves routine physical examinations, medical tests, and periodic MRI scans.…”

Section: Discussionmentioning

confidence: 99%

Pediatric brainstem glioma: a rare childhood cancer - clinical profile, treatment, and challenges of management - a single-center experience from a developing country

Kumar Ghosh,

Zahangir Kabir,

Kumar Saha

2024

JPNC

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Introduction: Brainstem gliomas (BSGs) occur in the brainstem, located at the base of the brain. BSGs account for 10-20% of all primary CNS tumors. In a hospital-based study conducted at NICRH, BSGs constituted 7.69% of all childhood brain tumors. Objective: To determine the clinical profiles of childhood BSGs and assess the outcomes of pediatric BSGs while addressing the challenges of management. Methodology: It was a cross-sectional prospective study with a sample size of 44. We included all children during the study period and analyzed their data.The children were under 18 years of age. The study period was January 2020 and October 2022 at the Department of Pediatric Hematology and Oncology at the National Institute of Cancer Research and Hospital (NICRH), Bangladesh. Results: There were 44 patients, comprising 29 males and 15 females. The mean age of onset was 7 years. The majority (43.2%) of children fell within the 5-9 years age group. The most common symptoms were limb weakness, ataxia, and vision defects. The duration of symptoms varied from 10 days to 2 years. Sixteen of the patients experienced intracranial hypertension, which led to the development of hydrocephalus. The lesions were pontine in 18 cases, involving the entire brainstem in 13 cases, both pons and medulla in 7 cases, and medulla in 3 cases. Six patients underwent surgical intervention with histological evaluation, revealing astrocytoma (9.1%), oligodendroglioma (2.3%), and ependymoma (2.3%). Twenty-four (54.5%) patients received treatment, while others were unable to do so. The follow-up period extended to 12 months from the last enrollment. Only 8 patients completed both chemotherapy and radiotherapy treatments; other children discontinued or abandoned treatment due to financial constraints or the unavailability of 3D radiotherapy. Out of 44 children, a total of 41 patients passed away, with a mean survival period of 3.9 months. This is due to the high treatment cost in the private sector and disorganized government medical services for children with cancer. Conclusion: Most of the tumors in this series were located in the pons and demonstrated aggressive characteristics. The majority of our patients did not have access to radiotherapy due to their poor economic condition and the inadequate management of our government health system.

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Section: Discussionmentioning

confidence: 99%