21st century miniguide to fungal biotechnology

Sánchez, Carmen; Moore, David; Robson, Geoff; Trinci, Tony

doi:10.29267/mxjb.2020.5.1.11

Cited by 12 publications

(9 citation statements)

References 120 publications

(111 reference statements)

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“…Fungi comprise a large and diverse kingdom of eukaryotic organisms morphologically classified as yeasts, filamentous fungi, or dimorphic fungi (Moore et al, 2020;Sánchez et al, 2020). These organisms can be saprotrophs (decomposing dead material), obligated or opportunistic organisms (decomposers, mutualists or pathogens) (Schmit & Mueller, 2007).…”

Section: Fungal Growth and Hyphal Major Componentsmentioning

confidence: 99%

Bioactive compounds from fungi with antiviral activities: Mechanism of action and biosynthetic pathways

Hernández-Sánchez¹,

Santacruz-Juárez²,

Moore³

et al. 2021

Mexjbiotechnol

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Viral infections have affected human health, causing critical pandemics and mortality worldwide. Viruses can also cause enormous economic problems for society globally. Bioactive compounds isolated from fungi (both edible and nonedible) have shown potential activity against viruses. In this review, we describe the fungal natural compounds that have exhibited capability to inhibit some human pathogenic viruses, such as human immunodeficiency virus, dengue virus, herpes simplex virus, bovine herpes virus, influenza virus, respiratory syndrome virus, hepatitis virus among others. We focused on the biosynthetic pathways of fungal bioactive compounds and addressed the current knowledge about their antiviral mechanisms of action and specific targets. Fungal bioactive compounds are able to inhibit viral reproduction, blocking viral penetration, replication or translation as well as integrase or protease action. Fungal compounds able to inhibit protease such as. ganodermatriol, ergosterol, terpenoids, ganoderic acid GS-2, ganoderiol, sterigmatocystin, emericellin, cordycepin, ergosterol peroxide, myristic acid among others, may have a significant value to society at present, as they may have the potential to treat severe viral respiratory infections. Fungi represent a potential natural source of bioactive molecules that can be exploited for treating viral infections, which represent one of the main causes of disease worldwide. However, extensive investigations on clinical trials are required for the introduction of new antiviral agents into the market.

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Section: Fungal Growth and Hyphal Major Componentsmentioning

confidence: 99%

Bioactive compounds from fungi with antiviral activities: Mechanism of action and biosynthetic pathways

Hernández-Sánchez¹,

Santacruz-Juárez²,

Moore³

et al. 2021

Mexjbiotechnol

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“…Ahuactzin-Pérez et al (2018) found that P. ostreatus degrades and uses as carbon and energy source high concentration (1000 mg/L) of di(2-ethyl hexyl) phthalate, which is a plasticizer that interfere with endocrine systems in mammals and has been detected as contaminant in the environment. The potential for using Pleurotus for pollutant and plastic degradation is discussed by Sánchez et al (2020).…”

Section: Pleurotusmentioning

confidence: 99%

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

Loftus¹,

Sánchez²,

Moore³

et al. 2020

Mexjbiotechnol

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We review the most recent developments in understanding the nature of development and morphogenesis in fungi and suggest how it might be applied to biotechnological manipulation of some cultivated mushrooms. We believe that it is essential to match the deductions of the molecular observations of the genomics generation with the inductive reasoning of the in vivo experiments and observations of the pregenomics generations to take full advantage of the synergism between the approaches to illuminate better the living biology of the system. As specific examples we show how model mushroom fungi (Coprinopsis and Volvariella) make hymenia and gills (not forgetting how the polypore Phellinus makes tubes), developmental commitment and pattern formation. The Coprinopsis sporophore also provides examples for the construction of mushroom stems and the coordination of cell behaviour throughout the maturing sporophore and the timing process that achieves that. This leads us to consider the mechanics of the mushroom and its dependence on the biochemistry and regulation of metabolism in relation to morphogenesis, and how it varies between species. We finish with our summary of the basic principles of fungal developmental biology. Having demonstrated how classic approaches allowed progress to be made in the study of fungal development we show how this has been accelerated by genomics and other aspects of global analysis of macromolecules. We also include work on some cultivated mushrooms to illustrate how the generalisations from research on model organisms might be applied in mushroom farming.

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“…On the other hand, fungi have a long association with humanity and have a profound biological and economic impact. Since ancient times, man has consumed wild mushrooms probably delicately, due to their pleasant taste [7]. They have a great nutritional value with a high content of proteins, vitamins, minerals, fibers, trace elements and low/no calories and cholesterol [8].…”

Section: Introductionmentioning

confidence: 99%

“…They have a great nutritional value with a high content of proteins, vitamins, minerals, fibers, trace elements and low/no calories and cholesterol [8]. Mushrooms have been described as a rich source of different bioactive substances such as antibacterial, antifungal, antiviral, antiparasitic, antioxidant, anti-inflammatory, antiproliferative, anticancer, antitumor, cytotoxic, anti-HIV, hypocholesterolemic, antidiabetic, anticoagulant and hepatoprotective compounds, among other [7,8,9]. Of the approximately 14,000 known species, 2,000 are safe for human consumption and about 650 possess medicinal properties [5].…”

Section: Introductionmentioning

confidence: 99%

“…In developing countries such as India and Mexico, with great biodiversity, mushrooms are a boon for progress in the field of food, medicine, and unemployment because they contain various nutracetics, there are also many medicinal mushrooms that are very useful for the development of human health as food, medicine, minerals, and drugs among others [4,7].…”

Section: Introductionmentioning

confidence: 99%

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The Use of the Biomass of a Macromycete Fungus for the Bioremediation of Chromium (VI) in Solution

Rodríguez

Domínguez

Pérez

et al. 2021

JAMB

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Recently, the removal capacity of different heavy metals from sites contaminated by low-cost materials has been studied, with promising results. These adsorbents include dead microorganisms, clay minerals, agricultural waste, industrial waste, and other materials. The objective of this work was studying the removal capacity of Cr (VI) by a commercial mushroom, the macromycete Agaricus bisporus (white strain), by the Diphenylcarbazide colorimetric method It was found that the biomass removal 100 mg/L of the metal at 21 minutes, pH 1.0, 28oC, and 100 rpm. On the other hand, if the concentration of the metal is increased, the removal capacity for the analyzed biomass decreases at 28oC. 200 mg/L are removal at 60 minutes, while with 1 g/L of the metal, its removal 90.3%. If the concentration of the bioadsorbent is increased, the removal of the metal also increases, and the presence of other heavy metals does not influence in the removal of the metal, and this was desorbed 70.4%, with NaOH 0.5 N. Finally, it was observing that after 7 days of incubation, 76.2%, and 66.1%, of Cr (VI) present in naturally contaminated earth and water, were removal, respectively.

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21st century miniguide to fungal biotechnology

Cited by 12 publications

References 120 publications

Bioactive compounds from fungi with antiviral activities: Mechanism of action and biosynthetic pathways

Bioactive compounds from fungi with antiviral activities: Mechanism of action and biosynthetic pathways

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

The Use of the Biomass of a Macromycete Fungus for the Bioremediation of Chromium (VI) in Solution

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