224 Ambulatory Blood Pressure and Metabolic Syndrome in Adolescents

Abstract

Diastolic function (DF) of the left ventricle (LV) in hypertension should be independent of left ventricular hypertrophy (LVH). Objectives: To determine the impact of metabolic syndrome (MS) in the development of diastolic dysfunction in hypertensive patients (p) with and without LVH. Methods: MS as ATP III criteria, LVH measured by echocardiography according to Devereux's method. LVH was considered a left ventricular mass index (LVMI) Ͼ 50 g/m 2 ; DF assessed by mitral valve orifi ce Doppler and tissue Doppler of the septal wall of LV. Waves E / A ratio, isovolumic relaxation time (IVRT), waves E / E´ ratio and waves E' / A' ratio were measured, and normal values of the Consensus of the European Society of Cardiology corrected for age were considered. Students t test for differences in means and proportions were applied, and it was considered statistically signifi cant p Ͼ 0.05. Results: 193 p included, mean age 60.9 ϩ -11.8 years, male 97 P (50.3%), mean BMI 28.5 ϩ 5.7 kg/ m 2 , 16 p (8.3%) had diabetes, mean blood pressure 137 ϩ -17 / 77 ϩ -11 mmHg. The table shows the analysis of diastolic function: LVH YES LVH NO MS YES MS NO MS YES MS NO N 5 1 2 Federation, Federal Center of Heart, Blood and Endocrinology n.a. V.A. Almazov Saint -Petersburg, Russian FederationAdipose tissue is an endocrine organ, which have important roles in the regulation of insulin sensitivity, infl ammation and lipid metabolism. Such adipokines include adiponectin and resistin.Aim To evaluate serum adiponectin (AN) and resistin (RES) levels in hypertensive patients with abdominal obesity aged 30-55 years. MethodsWe examined 232 patients (mean age 46.01 Ϯ 0.41) with abdominal obesity (AO) (IDF, 2005) (172 women и 60 men) and 40 healthy subjects without AO. 39.9% of patients were overweight (BMI 28.01 Ϯ 0.14 kg/m 2 ), 60.1% were obese (BMI 35.11 Ϯ 0.36 kg/m 2 ). 76.4% of patients were hypertensive. RES and AN levels were evaluated by ELISA (DRG, USA).Results: Serum AN level in patients with abdominal obesity and healthy subjects did not differ (p Ͼ 0.05). RES level in patients with abdominal obesity was higher than in healthy subjects (4.5 Ϯ 0.1 µg/ml and 3.1 Ϯ 0.03 µg/ml, p Ͻ 0.05). RES levels were higher in women with abdominal obesity than in men (4.8 Ϯ 0.2 µg/ml and 3.6 Ϯ 0.4 µg/ml, p Ͻ 0.05). Serum RES level in patients with abdominal obesity did not vary among overweight and obese patients (4.2 Ϯ 0.3 µg/ml and 4.6 Ϯ 0.2 µg/ml, p Ͼ 0.05). Plasma adiponectin level was higher in overweight patients than in obese patients (22.3 Ϯ 0.9 ng/ml and 19.7 Ϯ 0.7 ng/ml, p Ͻ 0.05).Serum AN and RES levels in patients with arterial hypertension and normotensive subjects did not differ (20.5 Ϯ 0.9 ng/ml and 20.5 Ϯ 0.8 ng/ ml, p Ͼ 0.05; 4.7 Ϯ 0.2 g/ml and 4.2 Ϯ 0.2 g/ml, p Ͼ 0.05). ConclusionsResistin level of obesity patients both hypertensive and normotensive was higher, than in healthy persons; adiponectin level in patients with arterial hypertension and normotensive subjects did not differ.Objective To study the ambulatory blood pressure (ABP) in...