228 Origin of Phase 3 of the Migrating Motor Complex Differs Between Lean and Obese Subjects

Motilin-induced gastric contractions signal hunger in man

“…Paradoxically, when motilin plasma levels do not decrease upon food intake, food intake capacity in man is diminished because of an inhibitory effect of motilin on gastric accommodation 14. In obese patients, gastric phase III activity occurs less frequently than in healthy volunteers 38 42. In addition, the rise in motilin release in synchrony with phase III activity is reduced in obese subjects 38.…”