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Tsirkin, V. I.; Nozdrachev, A. D.; Sazanova, Maria; Dvoryanskii, S. A.

doi:10.1023/a:1022431506880

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Contractile activity of strips was recorded on a Miotsitograf 6-channel device [7] at 38 o C. The working chamber was perfused with Krebs solution at a flow rate of 0.7 ml/min and passively aerated. The initial load was 500 mg (4.9 mN).…”

Section: Methodsmentioning

confidence: 99%

Influence of lysophosphatidylcholine, phosphatidylcholine, and hen egg yolk on contractile effects of acetylcholine on smooth muscles of rat stomach

Kunshin

Tsyrkin

2007

Bull Exp Biol Med

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Experiments on smooth muscles of rat stomach showed that lysophosphatidylcholine in concentrations of 10(-8) and 10(-7) g/ml does not modulate the tonotropic effect of acetylcholine (10(-6) g/ml), in a concentration of 10(-6) g/ml potentiated this effect (similarly to phosphatidylcholine, 10(-6) g/ml), and reduced it in concentrations of 10(-5)-10(-4) g/ml (similarly to hen egg yolk in dilutions of 1:500, 1:100, and 1:500). These data indicate that lysophosphatidylcholine modifies signal transduction from the receptor to G protein.

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Section: Methodsmentioning

confidence: 99%

Influence of lysophosphatidylcholine, phosphatidylcholine, and hen egg yolk on contractile effects of acetylcholine on smooth muscles of rat stomach

Kunshin

Tsyrkin

2007

Bull Exp Biol Med

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“…The phase of metestrus or diestrus was estimated by examination of vaginal smears. Contractile activity (CA) was recorded at 38 o C under passive aeration of 1-ml working chambers [8]. We used a 6-channel Myocytograph device constructed from an H-3020 automatic recorded, 6MX1C mechanotron, thermostatic system, and syringe injector.…”

Section: Methodsmentioning

confidence: 99%

Ability of L-histidine to decrease desensitization of the myometrium to epinephrine

2004

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Experiments were performed with 62 longitudinal strips of the uterine horns from 10 nonpregnant rats. The ability of continuously infused epinephrine in high concentration (10(-6) g/ml, 30 min) to suppress spontaneous contractions due to activation of beta-adrenoceptors progressively decreased, which was associated with receptor desensitization. Histidine in a concentration of 3 x 10(-11) g/ml had no effect, while in concentrations of 3 x 10(-8), 3 x 10(-7), and 3 x 10(-6) g/ml decreased the degree of desensitization. Our results indicate that histidine not only potentiates beta-adrenoceptor activation, but also prevents the development of desensitization. These data should be taken into account during therapy with beta-adrenoceptor agonists.

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Endogenous sensitizer of Beta-Adrenergic receptors (Esbar) and its analogs (Review)

Victor¹,

Alexander²,

Elena³

et al. 2018

J Cardiol Cardiovasc Med

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Untitled

Cited by 3 publications

References 2 publications

Influence of lysophosphatidylcholine, phosphatidylcholine, and hen egg yolk on contractile effects of acetylcholine on smooth muscles of rat stomach

Influence of lysophosphatidylcholine, phosphatidylcholine, and hen egg yolk on contractile effects of acetylcholine on smooth muscles of rat stomach

Ability of L-histidine to decrease desensitization of the myometrium to epinephrine

Endogenous sensitizer of Beta-Adrenergic receptors (Esbar) and its analogs (Review)

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