23. αγ-Diaminobutyric acid

The biological action of substances related to thyroxine. 6. The effect of compounds containing fragments of the thyroxine molecule on the oxygen consumption of mice

“…2:6-Diiodoanisole and 3:5-diiodo-4-methoxyphenol were moderately active, but 2:6diiodophenol was without action. This suggests that some distribution effect governing rates of absorption and cell penetration, such as those discussed by Wilkinson (1953), is responsible for this difference in activity.…”

“…C7H,0212 requires C, 22-3; H, 1-6; I, 67.6%.) 3:5-Diiodo-4-methoxytoluene was obtained from 2:6diiodo-p-cresol (Datta & Prosad, 1917) by the method of Wilkinson (1951).…”

The biological action of substances related to thyroxine. 2. Further derivatives of 3:5-diiodo-4-hydroxybenzoic acid

“…Methyl 3:5-diiodo-4-ethoxybenzoate was prepared from 3:5-diiodo-4-ethoxybenzoic acid (Wilkinson, 1951) (1-5 g.), methanol (30 ml.) and H2SO4 (3 drops) by the method used for ethyl 3:5-diiodo-4-methoxybenzoate.…”

“…The ethyl and benzyl ethers of the hydroxy aldehyde were obtained by the methods used for the preparation of the corresponding ethers of the diiodohydroxybenzoates (Wilkinson et al 1951). The ethyl ether was characterized as its oxime and dimethyl acetal, and the benzyl derivative was converted into its dimethyl acetal by the usual procedure.…”

Aminoglycosides. V. Synthesis of glucopyranoside derivatives of neamine modified in the 2-deoxystreptamine ring.

“…The mixture was stirred an additional 2 hours, adjusted to pH 6 THE JOURNAL OF ANTIBIOTICS JAN. 1981 with acetic acid and the solution was concentrated in vacuo to give crude, syrupy 2,4-bis(N-acetylamino) pentane-l,5-diol (20). This syrup was dissolved in 50 ml of 3 N HCl, refluxed for 3 hours, concentrated to a small volume in vacuo and adjusted to pH 7 with 20% NaOH solution.…”