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The presence in certain pathological urines of protein-like material which is not coagulated by heat has been realized for some years. It has been called mucin, mucoid, nucleoprotein, phosphoprotein, mucoprotein and nucleoalbumin by different investigators and has usually been detected by the turbidity produced on rendering the diluted urine acid with acetic acid. The isolation and characterization of a similar substance in normal urine was first reported by Tamm & Horsfall (1950, 1952), who employed two methods of isolation, one relying on ethanol precipitation and the other on saltingout with 0-58M sodium chloride. Yields in both cases were of the order of 2-2-5 mg./100 ml. of urine. Data on this substance suggest that the term 'mucoprotein' is appropriate (Tamm &

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