24-Hour rhythms in oxidative stress during hepatocarcinogenesis in rats: effect of melatonin or α-ketoglutarate

Subramanian, Perumal; Dakshayani, Kadiyala Babu; Pandi-Perumal, Seithikurippu R.; Trakht, Ilya; Cardinali, Daniel P.

doi:10.1179/135100008x259178

Cited by 24 publications

(24 citation statements)

References 38 publications

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“…19,20 It seems that a temporal relation may be observed between the circadian rhythm in MDA and 24-hour variations of some antioxidant enzymes, including the CAT, that is considered as a key antioxidant in erythrocytes. 49,50 In the present study, the oscillation in CAT activity, although significant, exhibited only a low amplitude and the rhythm was not detected. The presence of more than two peak times (within the 24-hour scale) occurred both at the rest and the activity span, presumably indicating that the curve pattern is somewhat nonsinusoidal.…”

Section: Discussioncontrasting

confidence: 71%

Circadian (about 24-hour) variation in malondialdehyde content and catalase activity of mouse erythrocytes

Sani

Sebaï²,

Ghanem-Boughanmi³

et al. 2014

Redox Report

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Lipid peroxidation is a part of normal metabolism that may cause biological molecule damage leading to the formation of several specific metabolites that include aldehydes of variable chains, such as malondialdehyde (MDA). These biological effects are controlled in vivo by a wide spectrum of enzymatic and non-enzymatic defense mechanisms among which catalase (CAT) is considered as an important regulator of oxidative stress. The present study aimed to investigate the possible relationship between the temporal patterns of the formation of MDA and the activity of CAT in the erythrocytes of mice. Twenty-four-hour studies were performed on male Swiss albino mice, 12 weeks old, synchronized to a 12:12 light: dark cycle for 3 weeks. Different and comparable groups of animals (n = 10) were sacrificed at an interval of 4 hours (1, 5, 9, 13, 17, and 21 hours after light onset (HALO)). The levels of erythrocyte MDA concentration and CAT activity both significantly (analysis of variance: F = 6.4, P < 0.002) varied according to the time of sampling under non-stressed conditions. The characteristics of the waveform describing the temporal patterns differed between the two studied variables, e.g. MDA content showing one peak (≅21 HALO) and CAT activity showing three peaks (≅9, 17, and 21 HALO). Cosinor analysis revealed a significant (adjusted Cosinor: P ≤ 0.018) circadian (τ ≅ 24 hours) rhythm in MDA level and no statistically significant rhythmicity in CAT activity. The differences and the absence of correlation between the curve patterns of erythrocyte MDA content and CAT activity under physiological conditions are hypothesized to explain that variation in lipid peroxidation may depend on several factors. Moreover, the identification of peak/trough levels of MDA accumulation in erythrocytes may reflect the degree of oxidative stress in these blood cells. In addition, the observed significant time-of-day effect suggests that, in both clinical and scientific settings, appropriate comparison of MDA production and CAT activity levels can only be achieved on data obtained at the same time of day.

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Section: Discussioncontrasting

confidence: 71%

Circadian (about 24-hour) variation in malondialdehyde content and catalase activity of mouse erythrocytes

Sani

Sebaï²,

Ghanem-Boughanmi³

et al. 2014

Redox Report

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“…36 More recently, mitochondrial effects of melatonin have come into focus, including safe-guarding of respiratory electron flux, reduction of oxidant formation by lowering electron leakage) and inhibition of opening of the mitochondrial permeability transition pore. 37 Since most of published studies on neuroprotective activity of melatonin were performed at single time points, generally at morning hours, and in view of the 24-h changes in redox state that occurs in a number of tissues, 38,39 it should be important to include a chronopharmacological approach in the analysis of the above mentioned effects of melatonin. Further studies are needed to shed light on the mechanisms that explain melatonin activity on HO-1 and HO-2 gene expression.…”

Section: Discussionmentioning

confidence: 99%

24-Hour variation in gene expression of redox pathway enzymes in rat hypothalamus: effect of melatonin treatment

et al. 2009

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The 24-h changes in medial basal hypothalamic (MBH) gene expression of redox pathway enzymes nitric oxide synthase (NOS)-1 and NOS-2, heme oxygenase (HO)-1 and HO-2, Cu/Zn- and Mn-superoxide dismutases (SOD) and catalase were examined in adult male Wistar rats kept under an alternating regimen of light/dark. Half of the animals received melatonin (approximately 60 microg/day) in the drinking water. After 1 month, rats were killed at six different time intervals, throughout a 24-h cycle. MBH mRNA levels were measured by real-time PCR analysis. In controls, gene expression of NOS-2 and HO-2 peaked at the early light phase while that of HO-1 showed a maximum at the middle of the dark phase. None of MBH mRNAs encoding NOS-1, Cu/Zn-SOD, Mn-SOD and catalase exhibited significant 24-h variations in control rats. Melatonin administration decreased significantly mRNAs for NOS-1, NOS-2, HO-1 and HO-2 as well as changed their 24-h profile. Melatonin augmented gene expression of the antioxidant enzymes Cu/Zn-SOD, Mn-SOD or catalase at certain time intervals only. The results are compatible with the view that the principal indirect (i.e. gene expression of redox pathway enzymes) effect of melatonin on redox pathway in the hypothalamus is mainly exerted via down-regulation of pro-oxidant enzyme mRNAs.

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“…The amplitude and mesor values of these antioxidant indices were significantly increased and the mesor values of TBARS were decreased after melatonin administration. Melatonin also reversed further delays in acrophase in NDEA-induced rats [169,170]. …”

Section: Protective Effects Of Melatonin On Hepatocarcinomamentioning

confidence: 99%

Effects of Melatonin on Liver Injuries and Diseases

Zhang

Meng

et al. 2017

IJMS

103

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Liver injuries and diseases are serious health problems worldwide. Various factors, such as chemical pollutants, drugs, and alcohol, could induce liver injuries. Liver diseases involve a wide range of liver pathologies, including hepatic steatosis, fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocarcinoma. Despite all the studies performed up to now, therapy choices for liver injuries and diseases are very few. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries and diseases remains a priority. Melatonin is a well-known natural antioxidant, and has many bioactivities. There are numerous studies investigating the effects of melatonin on liver injuries and diseases, and melatonin could regulate various molecular pathways, such as inflammation, proliferation, apoptosis, metastasis, and autophagy in different pathophysiological situations. Melatonin could be used for preventing and treating liver injuries and diseases. Herein, we conduct a review summarizing the potential roles of melatonin in liver injuries and diseases, paying special attention to the mechanisms of action.

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24-Hour rhythms in oxidative stress during hepatocarcinogenesis in rats: effect of melatonin or α-ketoglutarate

Cited by 24 publications

References 38 publications

Circadian (about 24-hour) variation in malondialdehyde content and catalase activity of mouse erythrocytes

Circadian (about 24-hour) variation in malondialdehyde content and catalase activity of mouse erythrocytes

24-Hour variation in gene expression of redox pathway enzymes in rat hypothalamus: effect of melatonin treatment

Effects of Melatonin on Liver Injuries and Diseases

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