240 Polymorphism of endothelial nitric oxide synthase gene in patients with erectile dysfunction

Erkan, E.; Müslümanoğlu, Ahmet Yaser; Merder, Erkan; Tefekli̇, Ahmet; Akbaş, Feray; Özbek, Uğur; Kadıoğlu, Ateş

doi:10.1016/s1569-9056(04)90241-2

Cited by 11 publications

(17 citation statements)

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“…Ho we ver, the ir re sults fa i led to show a sig ni fi cant cor re la ti on bet we en ED and eNOS4a/b ge ne poly morp hism (p= 0.813). In our com mu nity, Er kan et al 43 did not find any as so ci a ti on bet we en ED and eNOS 4a/b ge ne poly morp hism. Ho we ver, they fo und that 80% of the pa ti ents with se ve re ED and 54.5% of the di a be tic pa ti ents with ED had eNOS4a/b ge noty pe, sug ges ting that di a be tic pa tients with ED tended to ha ve this ge noty pe.…”

Section: Discussioncontrasting

confidence: 46%

Association of Angiotensin-Converting Enzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction

Cam¹,

Gümüş²,

Var³

et al. 2011

Turkiye Klinikleri J Med Sci

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432rectile dysfunction (ED) is defined as the inability to achieve and maintain an erection sufficient to permit satisfactory sexual intercourse, 1 and is a frequent chronic disorder increasing with age. In a community-based random sample observational study, 2 the total prevalen- Association of Angiotensin-ConvertingEnzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Re cent stu di es sug gest that an gi o ten sin II and nit ric oxi de (NO) may mo du la te pe ni le smo oth musc le to ne and con trac ti lity. Be ca u se ge noty pes of the an gi o ten sin con ver ting enz yme (ACE) and en dot he li al nit ric oxi de syntha se (eNOS) poly morp hisms ha ve be en as so ci a ted with di sor ders in the vas cu lar system, in this study, we in ves ti ga ted an as so ci a ti on bet we en the ACE I/D and eNOS G894T ge ne poly morp hisms and erec ti le dysfunc ti on (ED). M Ma a t te e r ri i a al l a an nd d M Me et t --h ho od ds s: : A to tal of 44 pa ti ents and 45 con trol sub jects we re inc lu ded in the study. Di ag no sis of erec tile dysfunc ti on (< 26) was pro vi ded by In ter na ti o nal In dex of Erec ti le Func ti on (II EF). The ACE I/D ve eNOS G894T ge ne poly morp hisms we re ge noty ped using PCR and RFLP. R Re e s su ul lt ts s: : No sig ni fi cant ca se-con trol dif fe ren ce was ob ser ved for the ACE I/D and eNOS G894T ge ne poly morp hisms either by ge noty pe or al le le fre qu en ci es [(ACE I/D-X 2 = 0.930 p= 0.628) and eNOS 894 G/T-X 2 = 2.114 p = 0.348)]. In addition, the re was no sig ni fi cant dif fe ren ce bet we en ACE I/D (X 2 = 3.174 p= 0.787) and eNOS G894T (X 2 = 4.320 p= 0.633) and II EF sco res among the pa ti ent gro up. C Co on nc c l lu u s si i o on n: : In this study, no as so ci a ti on was fo und bet we en ACE I/D and eNOS G894T ge ne poly morp hisms and erecti le dysfunc ti on in the Tur kish po pu la ti on stu di ed.K Ke ey y W Wo or rd ds s: : Erec ti le dysfunc ti on; poly morp hism, angiotensin-converting enzyme Ö ÖZ ZE ET T A Am ma aç ç: : Ya pı lan ça lış ma lar da nit rik ok sit (NO) ve an ji yo ten sin II'nin pe nil düz kas la rın to nüs ve kon trak ti li te si ni et ki le ye bil di ği ile ri sü rül mek te dir. An ji yo ten sin dö nüş tü rü cü en zim (ACE-ADE) ve en do te li yal nit rik ok sit sen taz (eNOS) gen po li mor fizm le ri da mar has ta lık la rı ile iliş ki li ol duk ların dan, bu ça lış ma da, erek til dis fonk si yon ile eNOS 894 G/T (Glu298Asp) ve ACE I/D gen po li morfizm le ri ara sın da ki iliş ki nin in ce le me si amaç lan mış tır. G Ge er re eç ç v ve e Y Yö ön n t te em ml le er r: : Ça lış ma ya erek til dis fonk si yo nu (ED) olan 44 has ta ile 45 sağ lık lı kon trol gru bu alın dı. ED ta nı sı (< 26), Ulus la ra ra sı Erek til Fonk si yon İndek si ne (II EF) gö re de ğer len di ril di. Has ta ve kon trol gru bun da ACE I/D ve eNOS 894 G/T gen po li mor fizm le ri, po li me raz zin cir re ak si yo nu ve kı sıt la yı cı en zim ke si mi yön tem le ri ile sap tan dı. B ...

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Section: Discussioncontrasting

confidence: 46%

Association of Angiotensin-Converting Enzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction

Cam¹,

Gümüş²,

Var³

et al. 2011

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

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“…In the remaining nine articles eligible for the meta‐analysis, six studies provided data on the association between G894T polymorphism and ED [19–21,36–38], five on 4 VNTR [20,36,39–41], one on IVF 23 + 10 G/T [36], and one on T‐786C [41]. One study investigated G894T and 4 VNTR polymorphisms [20], one investigated three polymorphisms: G894T, 4 VNTR and IVF 23 + 10 G/T [36], and one investigated 4 VNTR and T‐786C polymorphisms [41].…”

Section: Resultsmentioning

confidence: 99%

Endothelial Nitric Oxide Synthase Polymorphisms and Erectile Dysfunction: A Meta-Analysis

Wang

Gao

et al. 2010

The Journal of Sexual Medicine

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Introduction Erectile dysfunction (ED) is a common disorder noted for affecting quality of life. Several studies have reported the influence of endothelial nitric oxide synthase (eNOS) polymorphisms on ED susceptibility. However, results of association studies with individually low statistical power are conflicting. Aim Our study aimed to carry out a meta-analysis estimating the association between eNOS variants and the risk of ED. Methods Studies regarding the association between eNOS polymorphisms and ED were searched in Medline and Embase databases. The relevant studies that met the inclusion criteria were eligible for the analysis. Main Outcome Measures Five genetic models and a generalized odds ratio (ORG) were used to estimate the association between eNOS G894T and variable number of 27-bp tandem repeats in intron 4 (4 VNTR) and the risk of ED. Results Nine articles were included in our meta-analysis. Overall, significant association between the 894T variant and an increased risk of ED was derived for all genetic contrasts except for the recessive model (allele contrast: OR=1.64, 95% confidence interval [CI]: 1.03–2.60). The meta-analysis based on the ORG also produced significant results: ORG =1.64, 95% CI: 1.03–2.61. Significant heterogeneity and publication bias were detected. The cumulative meta-analysis showed the OR increased from 2003 to 2009 and then declined in 2010. Instability in the relative change of OR was observed. Regarding 4 VNTR and its association with ED, the overall analysis showed a lack of significant association (OR=0.96, 95% CI: 0.72–1.28). No evidence for heterogeneity among studies was observed. Subgroup analysis by ethnicity and recruitment strategy also yielded nonsignificant results. Conclusion The result supports that G894T variant is associated with an increase in the risk of ED. No evidence for a significant association between 4VNTR and ED is observed. The results of the present meta-analysis should be interpreted with caution. Further confirmation in large and well-designed studies is needed.

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“…Existing data about the associations between the eNOS G894T gene polymorphisms and ED are limited [13–17]. Thus, the aim of the present study was to investigate the possible correlations between eNOS exon 7 G894T gene, intron 4 VNTR polymorphisms, and ED in a Turkish population.…”

Section: Introductionmentioning

confidence: 93%

eNOS Gene Intron 4 VNTR and Exon 7-G894T Polymorphisms in Turkish Men with Erectile Dysfunction: A Case Control Study

Erol

Bozdogan

Akduman

et al. 2009

The Journal of Sexual Medicine

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Introduction The associations between the gene polymorphisms and erectile dysfunction (ED) are limited. Aim To examine a potential association between variable number of tandem repeats (intron 4 VNTR), G894T polymorphisms, and ED in Turkish men. Methods Sixty-four men with ED and 82 healthy men as a control group were included in the study. The patients were evaluated by medical history, International Index of Erectile Function (IIEF), serum glucose, and lipid profiles. VNTR and G894T polymorphism were assessed by isolated DNA blood samples obtained from the patient group with ED and controls. Main Outcome Measures Assesment of IIEF and VNTR and G894T polymorphism in the isolated DNA blood samples. Results Genotype distributions of endothelial nitric oxide syntase (eNOS) gene intron 4 VNTR polymorphisms in the patient group were similar to those in the healthy group (P > 0.05). The frequency of the eNOS gene intron 4 genotype was found as bb: 55 (67.1%), ab: 26 (31.7%), and aa: 1 (1.2%) in the controls and bb: 43 (67.2%), ab: 19 (29.7%), and aa: 2 (3.1%) in the patient group. The frequency of the G894T was found as gg: 61 (74.4%), gt: 21 (25.6%), and tt: 0 (0.0%) in the controls and gg: 32 (50.0%), gt: 27 (42.1%), and tt: 5 (7.8%) in the patient group (P = 0.002). The frequencies of the “t” allele were 21 (12.8%) in the control group and 37 (28.9%) in the patient group (P = 0.001). Logistic regression analysis showed that G894T polymorphism was an independent risk factor for ED. Conclusions We found significant differences in allelic and genotypic frequencies between patients and controls for the G894T eNOS polymorphisms. The presence of 894T allele in carriers increased the risk of ED. No association was found between VNTR polymorphism and in patients with ED.

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240 Polymorphism of endothelial nitric oxide synthase gene in patients with erectile dysfunction

Cited by 11 publications

References 0 publications

Association of Angiotensin-Converting Enzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction

Association of Angiotensin-Converting Enzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction

Endothelial Nitric Oxide Synthase Polymorphisms and Erectile Dysfunction: A Meta-Analysis

eNOS Gene Intron 4 VNTR and Exon 7-G894T Polymorphisms in Turkish Men with Erectile Dysfunction: A Case Control Study

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