25-Hydroxyvitamin D Is Associated with Kidney Function: The Dong-gu Study

Abstract

Although the kidneys play a leading part in the biosynthesis of vitamin D, there is no consensus regarding the relationship of the vitamin D concentration with kidney function. Thus, we aimed to estimate the correlation among 25-hydroxyvitamin D (25(OH)D), estimated glomerular filtration rate (eGFR), and albumin/creatinine ratio (ACR) in participants aged $50 y in Korea. This study consisted of 9,166 people who participated in a basic survey of the Dong-gu Study. Following an overnight fast, the blood and urine sample were assessed. The serum 25(OH)D, eGFR, ACR of each subject were measured. When adjusting for covariates and log-transformed ACR (Model III), the lower eGFR value was significantly associated with increasing 25(OH)D levels (

Correlation between Serum 25-Hydroxyvitamin D Level and Peripheral Arterial Stiffness in Chronic Kidney Disease Stage 3–5 Patients

“…Blood levels of 25-hydroxyvitamin D are considered indicative of human vitamin D status and can be taken to represent bone health and as an independent predictor of several chronic diseases [9,36]. Evidence had shown that 25-hydroxyvitamin D deficiency is related to albuminuria [9,10], impaired renal function [11], the need for long-term dialysis, and all-cause mortality [13]. Regarding the modulation of vascular functions, in vitro studies have demonstrated that 1,25-dihydroxyvitamin D can affect the proliferation of vascular smooth muscle cells and impair endothelium-dependent vasodilation because of the decreased bioavailability of vasodilators [15,16].…”

“…It has an established role in mineral homeostasis and musculoskeletal function and is also known to exert extra-skeletal effects, including modulation of endothelial function, immune function, inflammatory responses, and cell cycle regulation [9]. Deficiencies in 25-hydroxyvitamin D are associated with albuminuria [9,10] and impaired renal function in the general population [11] and all-cause mortality and kidney failure requiring long-term dialysis in pre-diabetic and DM patients [12,13]. Therefore, the reports of KDIGO (Kidney Disease: Improving Global Outcome) recommends regular measurement of serum levels to ensure sufficient vitamin D levels in patients with stage 3-5 CKD [14].…”

Associations Between 25-Hydroxyvitamin D, Kidney Function, and Insulin Resistance Among Adults in the United States of America

“…However, the association between 25(OH)D and kidney function has been controversial. Studies have shown that 25(OH)D has no protective effect on kidney function, and even has the opposite effect ( 7 , 8 ). There were even case reports of acute kidney failure caused by the use of vitamin D drops ( 31 ).…”

“…A previous study showed that even though 25(OH)D levels were sufficient, they did not seem to have the ability to protect kidney function ( 7 ). In addition, with increasing 25(OH)D levels, kidney function represented by eGFR significantly decreased ( 8 ).…”