25-Hydroxyvitamin D levels among healthy children in Alaska

Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents

“…In adults, functional measures [net calcium absorption efficiency (36), normal serum PTH concentrations (37,38), and fracture risk (39) The inverse association of vitamin D status with age during childhood and adolescence has not been well described. Prior studies examined children within a narrow age range, such as adolescence (11)(12)(13) or infancy and toddlerhood (14), which limited the ability of these studies to determine whether vitamin D status varied with age. One recent study in girls aged 4-8 y reported an inverse relation between age and 25(OH)D concentrations in blacks but not in whites (35).…”

“…25(OH)D concentrations were measured with the use of 125 I-labeled radioimmunoassay, which has excellent results when compared with the gold standard liquid chromatography method (54,55). Other pediatric studies (14,56) used a chemiluminescence assay that may have overestimated total 25(OH)D and underestimated 25(OH)D 2 (54,57). We collected detailed information on intake of vitamin D from dietary and supplemental sources, which showed the important contribution of vitamin D intake to vitamin D status.…”

“…Recent studies showed inadequate circulating 25(OH)D concentrations in adult medical inpatients (8), postmenopausal women (9), and free-living adults (10). In the pediatric population, several studies documented low serum vitamin D concentrations in adolescents living in Boston, Cleveland, and Maine (11)(12)(13), in infants and toddlers (14) in Alaska, and in children of primary school age in Lebanon (15). Of substantial concern, given the current obesity epidemic, is that obesity in children was also shown to be associated with decreased 25(OH)D concentrations (11,16); however, these prior studies determined obesity by using body mass index (BMI; in kg/m 2 ) rather than a more direct estimate of body fat mass.…”

Vitamin D deficiency in early childhood: prevalent in the sunny South Pacific

“…Unlike many other studies of young urban children, the vitamin D-deficient children in the current sample were not of low height-or weight-for-age (30)(31)(32)(33) . Neither breast-feeding past 6 months of age nor restrictive diets were associated with an increased risk of vitamin D deficiency (34,35) . In the present study inadequate dietary intake of vitamin D was not due to any parental omission or deliberate dietary restriction.…”

Vitamina D profiláctica

“…Diversos estudios de distintas partes del mundo (incluida España) muestran que un gran número de niños y adolescentes presenta una concentración sérica de 25(HO)D supuestamente insuficiente, sin objetivarse en muchos casos alteraciones esqueléticas ni alteraciones en el metabolismo del calcio 19,23 . Todavía queda por determinar con pruebas consistentes qué efectos tiene este déficit subclínico, el cual, como se ha comentado previamente, se ha asociado a múltiples patologías crónicas.…”