265 Genomic and metagenomic analysis of antibiotic resistance in dairy animals

Haley, Bradd J.; Kim, S. W.; Cao, H.; Karns, Jeffrey S.; Kessel, Jo Ann S. Van

doi:10.2527/asasann.2017.265

Cited by 3 publications

(2 citation statements)

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“…Some recent studies have focused on E. coli-associated ARG and confirmed herd-level resistome variability, sometimes with differences in ARG encoding resistance to the same antibiotic (Cao et al, 2017). Tetracycline resistance may be the most common, with a sequencing effort of 160 antibiotic-resistant E. coli and 28 fecal metagenomes indicating that 61% of all identified ARG encoded resistance to tetracycline (Haley et al, 2017). Similar findings were found in our recent study of 11 northeastern US dairy operations (Hurst et al, 2019).…”

Section: Arg In Untreated Dairy Manuresupporting

confidence: 83%

Invited review: Fate of antibiotic residues, antibiotic-resistant bacteria, and antibiotic resistance genes in US dairy manure management systems

Oliver

Gooch

Lansing

et al. 2020

Journal of Dairy Science

136

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United States dairy operations use antibiotics (primarily β-lactams and tetracyclines) to manage bacterial diseases in dairy cattle. Antibiotic residues, antibiotic-resistant bacteria (ARB), and antibiotic resistance genes (ARG) can be found in dairy manure and may contribute to the spread of antibiotic resistance (AR). Although β-lactam residues are rarely detected in dairy manure, tetracycline residues are common and perhaps persistent. Generally, <15% of bacterial pathogen dairy manure isolates are ARB, although resistance to some antibiotics (e.g., tetracycline) can be higher. Based on available data, the prevalence of medically important ARB on dairy operations is generally static or may be declining for antibiotic-resistant Staphylococcus spp. Over 60 ARG can be found in dairy manure (including β-lactam and tetracycline resistance genes), although correlations with antibiotic usage, residues, and ARB have been inconsistent, possibly because of sampling and analytical limitations. Manure treatment systems have not been specifically designed to mitigate AR, though certain treatments have some capacity to do so. Generally, well-managed aerobic compost treatments reaching higher peak temperatures (>60°C) are more effective at mitigating antibiotic residues than static stockpiles, although this depends on the antibiotic residue and their interactions. Similarly, thermophilic anaerobic digesters operating under steady-state conditions may be more effective at mitigating antibiotic residues than mesophilic or irregularly operated digesters or anaerobic lagoons. The number of ARB may decline during composting and digestion or be enriched as the bacterial communities in these systems shift, affecting relative ARG abundance or acquire ARG during treatment. Antibiotic resistance genes often persist through these systems, although optimal management and higher operating temperature may facilitate their mitigation. Less is known about other manure treatments, although separation technologies may be unique in their ability to partition antibiotic residues based on sorption and solubility properties. Needed areas of study include determining natural levels of AR in dairy systems, standardizing and optimizing analytical techniques, and more studies of operating on-farm systems, so that treatment system performance and actual human health risks associated with levels of antibiotic residues, ARB, and ARG found in dairy manure can be accurately assessed.

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Section: Arg In Untreated Dairy Manuresupporting

confidence: 83%

Invited review: Fate of antibiotic residues, antibiotic-resistant bacteria, and antibiotic resistance genes in US dairy manure management systems

Oliver

Gooch

Lansing

et al. 2020

Journal of Dairy Science

136

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“…Dairy farmers are using improved diagnostics (Lago, Godden, Bey, Ruegg, & Leslie, 2011; Vasquez, Nydam, Capel, Eicker, & Virkler, 2017), herd management (Kleinlützum, Weaver, & Schley, 2013; Lorenz, Mee, Earley, & More, 2011; Love et al., 2016), and housing (Lorenz, Earley, et al., 2011; Phillips et al., 2013) to reduce antibiotic usage. However, even prudent herd management and antibiotic administration can result in the detection of antibiotic residues (Ince, Coban, Turker, Ertekin, & Ince, 2013; Ray, Knowlton, Shang, & Xia, 2014), antibiotic‐resistant bacteria (ARB; Cummings, Perkins, Khatibzadeh, Warnick, & Altier, 2013; NARMS, 2019), and antibiotic resistant genes (ARGs) in dairy cattle manure (Chambers et al., 2015; Haley, Kim, Cao, Karns, & Van Kessel, 2017). As such, there is a need to better understand the fate of antibiotics, ARB, and ARGs in dairy manure systems and their capacity to minimize AR before manure is recycled to cropland or as bedding (Oliver et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

On‐farm screw press and rotary drum treatment of dairy manure‐associated antibiotic residues and resistance

et al. 2021

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Core Ideas  Only sulfadimethoxine and oxytetracycline residues were detected in manure samples.  Most antibiotic resistance genes (ARGs) partitioned with separated manure liquids.  tetO was primarily associated with separated manure solids (SS).  A rotary drum composter (RD) treated SS from antibiotic-treated cattle.  The RD significantly reduced all four ARGs and oxytetracycline residues.

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When the solution becomes the problem: a review on antimicrobial resistance in dairy cattle

Pires,

Pereira,

Fangueiro

et al. 2024

Future Microbiology

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Antibiotics' action, once a ‘magic bullet’, is now hindered by widespread microbial resistance, creating a global antimicrobial resistance (AMR) crisis. A primary driver of AMR is the selective pressure from antimicrobial use. Between 2000 and 2015, antibiotic consumption increased by 65%, reaching 34.8 billion tons, 73% of which was used in animals. In the dairy cattle sector, antibiotics are crucial for treating diseases like mastitis, posing risks to humans, animals and potentially leading to environmental contamination. To address AMR, strategies like selective dry cow therapy, alternative treatments (nanoparticles, phages) and waste management innovations are emerging. However, most solutions are in development, emphasizing the urgent need for further research to tackle AMR in dairy farms.

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265 Genomic and metagenomic analysis of antibiotic resistance in dairy animals

Cited by 3 publications

References 0 publications

Invited review: Fate of antibiotic residues, antibiotic-resistant bacteria, and antibiotic resistance genes in US dairy manure management systems

Invited review: Fate of antibiotic residues, antibiotic-resistant bacteria, and antibiotic resistance genes in US dairy manure management systems

On‐farm screw press and rotary drum treatment of dairy manure‐associated antibiotic residues and resistance

When the solution becomes the problem: a review on antimicrobial resistance in dairy cattle

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