266 Mobilization of pluripotent haematopoietic stem cells occurs in alcoholic hepatitis and is associated with an improved clinical outcome

Dalakas, Evangelos; Newsome, Philip; Liu, Qing; Brown, R.; McCall, Shonna; Hayes, Peter; Harrison, David J.; Plevris, John

doi:10.1016/s0270-9139(03)80309-9

Cited by 6 publications

(4 citation statements)

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“…The response in BM was identical irrespective of whether the mice received CCl 4 or DLS, implicating that the observed cellular activities in BM were the effect of the soluble putative growth factors present in the serum. Studies in humans have shown that the PB-hematopoietic stem cell population is increased after extensive liver resection [30] and in patients suffering from alcoholic hepatitis [31].…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Potential Subpopulation of Bone Marrow Cells Involved in the Repair of Injured Liver Tissue

Khurana

Mukhopadhyay

2007

Stem Cells

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Section: Discussionmentioning

confidence: 99%

Characterization of the Potential Subpopulation of Bone Marrow Cells Involved in the Repair of Injured Liver Tissue

Khurana

Mukhopadhyay

2007

Stem Cells

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“…Indeed, increased numbers of circulating HSCs have been identified within the peripheral blood after various injury conditions both experimentally and clinically [3,22,23]. A number of factors are critical in retaining HSCs within the BM.…”

Section: Mechanisms Governing Hsc Mobilization From Bone Marrowmentioning

confidence: 99%

Hematopoietic Stem Cell Homing to Injured Tissues

Kavanagh

Kalia

2011

Stem Cell Rev and Rep

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The use of stem cells is considered a promising therapy for tissue regeneration and repair, particularly for tissues injured through degeneration, ischemia and inflammation. Bone marrow (BM)-derived haematopoietic stem cells (HSCs) are rare populations of multipotent stem cells that have been identified as promising potential candidates for treating a broad range of conditions. Although research into the use of stem cells for regenerative medicine is on a steep upward slope, clinical success has not been as forthcoming. This has been primarily attributed to a lack of information on the basic biology of stem cells, which remains insufficient to justify clinical studies. In particular, while our knowledge on the molecular adhesive mechanisms and local environmental factors governing stem cell homing to BM is detailed, our understanding of the mechanisms utilized at injured sites is very limited. For instance, it is unclear whether mechanisms used at injured sites are location specific or whether this recruitment can be modulated for therapeutic purposes. In addition, it has recently been suggested that platelets may play an important role in stem cell recruitment to sites of injury. A better understanding of the mechanisms used by stem cells during tissue homing would allow us to develop strategies to improve recruitment of these rare cells. This review will focus on the status of our current understanding of stem cell homing to injured tissues, the role of platelets and directions for the future.

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“…A recent study by De Silvestro et al demonstrated that peripheral blood HSC levels were elevated after extensive liver resection (36). Our group has demonstrated that in patients with alcoholic hepatitis there is an increase in circulating HSCs when compared with normal controls (37). The extent to which these peripheral blood HSCs are mobilized into the circulation of patients with liver injury and contribute to liver repair remains uncertain and is under investigation.…”

Section: Adult Stem Cell Mobilization and Recruitment In Liver Injurymentioning

confidence: 99%

Hematopoietic stem cell trafficking in liver injury

et al. 2005

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Bone marrow (BM) hematopoietic stem cells (HSCs) have been shown to facilitate regeneration in multiple nonhematopoietic tissues by either generating epithelial cells or altering the inflammatory response. Depending on injury type, the predominant mechanism of epithelial lineage regeneration occurs by spontaneous cell fusion or transdifferentiation. Irrespective of the mechanism, mobilization from the BM is a prerequisite. Mechanisms by which HSCs mobilize into damaged organs are currently under scrutiny. Murine and human studies have shown that the chemokine SDF-1 and its receptor CXCR4 participate in the mobilization of HSCs from BM and in the migration of HSCs to injured liver. SDF-1 is a potent HSC chemoattractant and is produced by the liver. Production is increased during liver injury leading to increased HSC migration to the liver, a finding diminished by neutralizing anti-CXCR4 antibodies. Additional factors have been implicated in the control of hepatic migration of HSCs such as IL-8, hepatocyte growth factor, and MMP-9. Matriceal remodeling is an essential component in HSC engraftment, and MMP-9 expression is increased in liver injury. This review focuses on the complex interaction of chemokines, adhesion molecules, and extracellular matrix factors required for successful migration and engraftment of HSCs into the liver.

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266 Mobilization of pluripotent haematopoietic stem cells occurs in alcoholic hepatitis and is associated with an improved clinical outcome

Cited by 6 publications

References 0 publications

Characterization of the Potential Subpopulation of Bone Marrow Cells Involved in the Repair of Injured Liver Tissue

Characterization of the Potential Subpopulation of Bone Marrow Cells Involved in the Repair of Injured Liver Tissue

Hematopoietic Stem Cell Homing to Injured Tissues

Hematopoietic stem cell trafficking in liver injury

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