297: The comparison of intratechal isobaric ropivacaine and isobaric ropivacaine-clonidine for caesarean delivery

Öğün, Cemile Öztin; Kirgiz, Esma Nur; Duman, Ateş; Kara, İnci; Ökesli, Selmin

doi:10.1016/j.rapm.2007.06.140

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…Ogunal et al studied effects of isobaric ropivacaine with dose of 15mg with morphine of 150 ug intrathecally and noted total duration of sensory block of 165.2min. In our study we observed total duration of 160.5 min, which is similar to their study [10].…”

Section: Resultssupporting

confidence: 91%

Comparative Study of Isobaric Ropivacaine with and without Morphine in Spinal Anaesthesia for Perineal Surgeries

V.P¹,

Ramesh²,

Choudhary³

2016

IJAR

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Objectives: The comparative study is under taken to evaluate use of intrathecal isobaric ropivacaine with and without adjuvant morphine in perineal surgeries. Aims: The aim of this study is to evaluate sensory block, motor block and other clinical effects with 3 ml of isobaric 0.5% ropivacaine along with 100µ morphine and without mophine intrathecally in Perineal surgeries . Methods: This study was conducted in 100 patients scheduled for elective Perineal surgeries. The patients were grouped as study and control group with 50 patients in each group. The study group received 3ml of 0.5% isobaric ropivacaine with 100µ morphine intrathecally and control group received only 3ml of 0.5% isobaric ropivacaine. Onset and duration of sensory block, motor block, quality of anaesthesia, time of request for analgesia, time for ambulation, VAS score, hemodynamic parameters and adverse effects if any were studied. Results: In present study faster in onset of sensory block with normal duration sensory block was observed in study group. In addition short duration of motor block, with early ambulation was noted in study group. Requirement of rescue analgesia was prolonged with duration of 5.92 hrs in study group in comparison to control group which was 4.00 hrs and this was statically significant. Conclusion: Intrathecal administration of Isobaric ropivacaine with 100µ morphine provides better quality of sensory block, faster onset sensory block with shorter duration of motor block, enabling early ambulation and significantly prolonged analgesia.

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Section: Resultssupporting

confidence: 91%

Comparative Study of Isobaric Ropivacaine with and without Morphine in Spinal Anaesthesia for Perineal Surgeries

V.P¹,

Ramesh²,

Choudhary³

2016

IJAR

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“…There is no significant difference, these results are in contrast with study done by SN Bhat et al 26 Mean time for first request of analgesic for Levobupivacaine was 262.22 ±36.60 and for Ropivacaine was 261.20 ± 32.71 min. There is no statistically significant difference, these results are similar to studies done by Bozkirli F et al 31 Taspinar et al 32 and Ogun C O et al 33 There was no statistically significant difference in the incidence of adverse events in both the groups. So both the drugs are considered to be safe in spinal anesthesia…”

Section: Discussionsupporting

confidence: 89%

Levobupivacaine versus ropivacaine in patients undergoing lower abdominal surgeries

Byndoor

Sagar

2023

IJPP

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Regional anesthesia, like Peripheral nerve block, is commonly used for peripheral surgeries to reduce severe intraoperative and postoperative pain relief. .Some studies with levobupivacaine have shown that duration of analgesia of levobupivacaine are longer compared to that of an equivalent dose of bupivacaine or ropivacaine.This study is done to compare efficacy and safety of levobupivacaine with ropivacaine. In this study we tried to compare efficacy and clinical characteristics of isobaric forms of intrathecal levobupivacaine 0.5% and ropivacaine 0.75% in lower abdominal surgeries.This prospective, observational and open labeled, comparative study done for a period of one year in a tertiary care health centre, in South India, prior approval from Institutional ethics committee was taken. 60 patients were included and each of 60 patients was randomized (sealed, numbered and opaque envelopes) to one of two groups of 30 patients. Each of the patients enrolled in the study received one of two solutions: levobupivacaine or Ropivacaine, patient was turned supine immediately after injection, time of which was defined as ‘zero’. Thereafter, investigator, assessed upper and lower limits of sensory block (analgesia to pinprick), degree of motor block and recorded heart rate and arterial pressure. The patients were then transferred into the operating theatre and assessments were continued at 30 min intervals thereafter until complete motor and sensory blocks regression. Data were analysed using a standard computer-based statistics package.Mean time of onset of sensory blockade for levobupivacaine was 3.85±0.5 min and in Ropivacaine was 3.90 ± 0.6 min. Mean time of onset of motor blockade in levobupivacaine group was 3.65 ± 0.72 min and in Ropivacaine group was 3.82 ± 0.88 min, mean duration of motor blockade in Levobupivacaine group was 201.15±22.06 min and in Ropivacaine group was 204 ± 21.20 min. Mean time for regression for levobupivacaine was 98.27±10.18 min and for ropivacaine was 96.33 ±8.21min. There is no significant difference, Mean time for first request of analgesic for Levobupivacaine was 262.22 ±36.60 and for Ropivacaine was 261.20 ± 32.71 min. There is no statistically significant difference; there was no statistically significant difference in the incidence of adverse events in both the groups. So both the drugs are considered to be safe in spinal anesthesia.In conclusion, Ropivacaine and Levobupivacaine has similar onset of sensory and motor blockade with comparable hemodynamic parameters and time for rescue analgesic administration was comparable between two groups and incidence of post- operative complications is not significant with both drugs.

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“…This auger well with results of Ogun and others also observed comparable hemodynamics in their study. 13 All the babies delivered in either-groups were healthy. None of the babies had APGAR score less than 7.…”

Section: Hemodynamic Parametersmentioning

confidence: 91%

“…In our study, patients receiving ropivacaine had delayed onset of grade 3 motor blockade compared to bupivacaine, this is in agreement with above-mentioned study and also study conducted by Ogun and others. 13…”

Section: Time For Onset Of Motor Blockmentioning

confidence: 99%

A comparative study of intrathecal isobaric ropivacaine and hyperbaric bupivacaine for elective lower segment caesarean section

Ramarao,

Laxman Rao,

Santhi Sree

et al. 2024

Int J Basic Clin Pharmacol

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Background: The study was to compare intrathecal isobaric ropivacaine and hyperbaric bupivacaine in terms of onset of sensory block, maximum height of sensory block, total sensory duration, onset of motor block, degree of motor block and duration of motor block, quality of anesthesia. Methods: The 100 cases of ASA II undergoing elective lower segment caesarean section were taken for the study and divided into two groups. Group B patients received 2 ml of hyperbaric bupivacaine intrathecally. Group R patients received 2ml of isobaric ropivacaine intrathecally. Patients were evaluated for onset and duration of sensory block, onset and duration of motor block, maximum height of sensory block, quality of anaesthesia, time to request for analgesia, hemodynamic parameters and side effects if any were studied. Results: There were no significant differences between the two groups in mean time to onset of sensory block. Maximum sensory height attained in group B ranged between T4 and T6, where as in group R, it ranged between T2 and T6 which was clinically and statistically highly significant (p<0.001). Total duration of sensory block in group B and in group R, which is not significant (p=0.068). Mean time onset of motor block was 4min in group B and 8 min in group R, (p<0.001). Duration of motor block was 155.20±14.95 min in group B and 94.10±8.31 min group R, which is clinically and statistically significant (p<0.001). Conclusions: Ropivacaine 15 mg (2 ml of 0.75% isobaric ropivacaine) provides comparable quality of sensory block but has slower onset and significantly shorter duration of motor block compared to bupivacaine.

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297: The comparison of intratechal isobaric ropivacaine and isobaric ropivacaine-clonidine for caesarean delivery

Cited by 3 publications

References 21 publications

Comparative Study of Isobaric Ropivacaine with and without Morphine in Spinal Anaesthesia for Perineal Surgeries

Comparative Study of Isobaric Ropivacaine with and without Morphine in Spinal Anaesthesia for Perineal Surgeries

Levobupivacaine versus ropivacaine in patients undergoing lower abdominal surgeries

A comparative study of intrathecal isobaric ropivacaine and hyperbaric bupivacaine for elective lower segment caesarean section

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