2B4 (CD244, SLAMF4) and CS1 (CD319, SLAMF7) in systemic lupus erythematosus and cancer

Malaer, Joseph D.; Marrufo, Armando M.; Mathew, Porunelloor A.

doi:10.1016/j.clim.2018.10.009

Cited by 19 publications

(15 citation statements)

References 54 publications

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“…Moreover, SLE patients have decreased expression of CD244 in monocytes and NK cells. Other research of CD244-deficient mice showed that regulation of NK cells by CD244 might be related to the gender-specific immune response in SLE (41,47,48). Genetic studies indicated that a single nucleotide polymorphism (SNP) in CD244 was related to SLE susceptibility, and that alternative splicing of the CD244 mRNA also regulated SLE progression (49,50).…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

“…However, research has also indicated a number of unresolved problems regarding CD244. For example, studies of SLE patients showed that CD244 had different regulatory effects in the same type of immune cells (CD8 + T cells) (46,47); some studies attributed this difference to the different regulatory effects of CD244 by different cell subtypes. However, this problem is not so simply resolved because CD244 also has different regulatory effects on virus-specific T cells in two diseases caused by HTLC-1 (ATL and HAM/TSP), and had adverse effects in both cases.…”

Section: Conclusion and Prospectmentioning

confidence: 99%

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Advances in Understanding the Roles of CD244 (SLAMF4) in Immune Regulation and Associated Diseases

Sun

Gang

et al. 2021

Front. Immunol.

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Proteins in the signaling lymphocytic activating molecule (SLAM) family play crucial roles in regulating the immune system. CD244 (SLAMF4) is a protein in this family, and is also a member of the CD2 subset of the immunoglobulin (Ig) superfamily. CD244 is a cell surface protein expressed by NK cells, T cells, monocytes, eosinophils, myeloid-derived suppressor cells, and dendritic cells. CD244 binds to the ligand CD48 on adjacent cells and transmits stimulatory or inhibitory signals that regulate immune function. In-depth studies reported that CD244 functions in many immune-related diseases, such as autoimmune diseases, infectious diseases, and cancers, and its action is essential for the onset and progression of these diseases. The discovery of these essential roles of CD244 suggests it has potential as a prognostic indicator or therapeutic target. This review describes the molecular structure and function of CD244 and its roles in various immune cells and immune-related diseases.

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Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Section: Conclusion and Prospectmentioning

confidence: 99%

Advances in Understanding the Roles of CD244 (SLAMF4) in Immune Regulation and Associated Diseases

Sun

Gang

et al. 2021

Front. Immunol.

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“…The role of CD48 as a costimulatory receptor of various immune responses is still being studied. The previous papers concentrated mainly on autoimmune diseases such as systemic sclerosis [18] or systemic lupus erythematosus [19], cancer (multiple myeloma [19] and acute myeloid leukemia [20]), and bacterial and other infectious diseases [21]. Interactions between CD48 and CD244 (2B4) on mast cells, eosinophils, and basophils suggest that these cell types can act synergistically in the “allergic effector unit” to promote inflammation.…”

Section: Discussionmentioning

confidence: 99%

Elevated Serum Level of CD48 in Patients with Intermittent Allergic Rhinitis

Branicka

Jura-Szołtys

Rogala

et al. 2020

Int Arch Allergy Immunol

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Background: In the pathogenesis of intermittent allergic rhinitis (IAR), the inflammatory reaction is of importance. CD48, belonging to the CD2 family, participates in mast cell-stimulating cross-talk, facilitates the formation of the mast cell/eosinophil effector unit, and is expressed by eosinophils. Objectives: To assess the serum level of soluble form of CD48 (sCD48) in patients with IAR during and out of the pollen season and correlate with the disease severity and with eosinophil-related parameters. Materials and Methods: Sixty-three patients (female: 79%; mean age: 30.58) were included to the study. Forty-five patients were assessed during the pollen season and other 42 patients during out of the pollen season. Twenty-four patients (female: 37.50%; mean age: 27.90) were evaluated twice, during the pollen season and out of the pollen season. sCD48, ECP, eotaxin-1/CCL11 serum levels together with complete blood count, and fractional exhaled nitric oxide bronchial and nasal fraction (FeNO) were performed. The severity of symptoms was assessed using the Total Nasal Symptom Score (TNSS), and neutrophil-to-lymphocyte (NLR) and eosinophil-to-lymphocyte (ELR) ratios were calculated. Results: sCD48 serum level, FeNO nasal and bronchial fractions, and TNSS were significantly higher in the IAR group in the pollen season compared with out of the pollen season. Differences in ECP, eotaxin-1/CCL11 serum levels, and NLR and ELR were not significant between season and out of the season. No correlations were found between sCD48 and eosinophil-related parameters. Conclusions: sCD48 may be a biomarker to the exacerbation phase in patients with IAR. One can assume that CD48 participates in the pathogenesis of IAR.

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“…Unveiling these mechanisms and events is required to identify new immunological cellular biomarkers, trace disease progression, and design new targeted therapeutic strategies for autoimmunity. In this scenario, re-education/manipulation of NK cells appear as a promising strategy, as confirmed by the growing interest in CAR-NK cells ( 136 ).…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 94%

Immunological Drivers in Graves' Disease: NK Cells as a Master Switcher

et al. 2020

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Graves' disease (GD) is a common autoimmune cause of hyperthyroidism, which is eventually related to the generation of IgG antibodies stimulating the thyrotropin receptor. Clinical manifestations of the disease reflect hyperstimulation of the gland, causing thyrocyte hyperplasia (goiter) and excessive thyroid hormone synthesis (hyperthyroidism). The above clinical manifestations are preceded by still partially unraveled pathogenic actions governed by the induction of aberrant phenotype/functions of immune cells. In this review article we investigated the potential contribution of natural killer (NK) cells, based on literature analysis, to discuss the bidirectional interplay with thyroid hormones (TH) in GD progression. We analyzed cellular and molecular NK-cell associated mechanisms potentially impacting on GD, in a view of identification of the main NK-cell subset with highest immunoregulatory role.

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2B4 (CD244, SLAMF4) and CS1 (CD319, SLAMF7) in systemic lupus erythematosus and cancer

Cited by 19 publications

References 54 publications

Advances in Understanding the Roles of CD244 (SLAMF4) in Immune Regulation and Associated Diseases

Advances in Understanding the Roles of CD244 (SLAMF4) in Immune Regulation and Associated Diseases

Elevated Serum Level of CD48 in Patients with Intermittent Allergic Rhinitis

Immunological Drivers in Graves' Disease: NK Cells as a Master Switcher

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