2D nanostructures beyond graphene: preparation, biocompatibility and biodegradation behaviors

Wang, Shige; Yang, Xueqing; Zhou, Lingling; Li, Jinfeng; Chen, Hangrong

doi:10.1039/c9tb02845e

Cited by 49 publications

(28 citation statements)

References 126 publications

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“…Multifunctional nanomaterials integrating therapeutic and imaging modalities have opened a new era in the present therapeutic strategies, namely, theranostics. Two-dimensional (2D) nanosheets, a type of brand-new nanomaterial, which could integrates multiple functionalities of various materials to obtain an ‘all-in-one’ platform is a potential starting point for translational research [ 148 ]. Passi et al designed a multifunctional silk fibroin-based carrier for the delivery of antioxidant and imaging agents.…”

Section: Introductionmentioning

confidence: 99%

Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review

Song

2020

J Nanobiotechnol

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Oxidative stress is significantly involved in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD). Combining antioxidant drugs or nutrients results in a noteworthy therapeutic value in animal models of COPD. However, the benefits have not been reproduced in clinical applications, this may be attributed to the limited absorption, concentration, and half-life of exogenous antioxidants. Therefore, novel drug delivery systems to combat oxidative stress in COPD are needed. This review presents a brief insight into the current knowledge on the role of oxidative stress and highlights the recent trends in novel drug delivery carriers that could aid in combating oxidative stress in COPD. The introduction of nanotechnology has enabled researchers to overcome several problems and improve the pharmacokinetics and bioavailability of drugs. Large porous microparticles, and porous nanoparticle-encapsulated microparticles are the most promising carriers for achieving effective pulmonary deposition of inhaled medication and obtaining controlled drug release. However, translating drug delivery systems for administration in pulmonary clinical settings is still in its initial phases.

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Section: Introductionmentioning

confidence: 99%

Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review

Song

2020

J Nanobiotechnol

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“…Considering these structural and compositional differences, their solubility, biodegradation, and biocompatibility could be different from each other. Presently, the evaluations of in vitro/vivo biocompatibility of these materials are in progress (Wang S. G. et al, 2020). Despite the low toxicities of several types of 2D NMs [e.g., MnO 2 (Gao et al, 2020), g-C 3 N 4 (Liang et al, 2017), and h-BN (Mateti et al, 2018)] exhibited in preliminary investigations, it is too soon to confirm the biosafety of 2D NMs at this stage.…”

Section: Biomedical Applications Of 2d Nanozymes Toxicology Of 2d Nmsmentioning

confidence: 99%

Two-Dimensional Nanomaterials With Enzyme-Like Properties for Biomedical Applications

Cai

Yang

2020

Front. Chem.

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Recently, remarkable progress has been made in nanozyme research due to the rapid development of nanomaterials. Two-dimensional nanomaterials such as metal nanosheets, graphene-based materials, transition metal oxides/dichalcogenides, etc., provide enhanced physical and chemical functionality owing to their ultrathin structures, high surface-to-volume ratios, and surface charges. They have also been found to have high catalytic activities in terms of natural enzymes such as peroxidase, oxidase, catalase, and superoxide dismutase. This review provides an overview of the recent progress of nanozymes based on two-dimensional nanomaterials, with an emphasis on their synthetic strategies, hybridization, catalytic properties, and biomedical applications. Finally, the future challenges and prospects for this research are discussed.

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“…In the last few decades, inorganic compounds with layered structure such as cationic and anionic clays (Choy, Kwak, Park, Jeong, & Portier, 1999; Choy, Kwak, Jeong, & Park, 2000; Choy, Oh, Park, Shon, & Kim, 2004; Khan & O'Hare, 2002; Ogawa & Kuroda, 1995; Vaccari, 1999), have been extensively studied in various research aspects; for example, flame retardants (Q. Wang, Zhang, Zhu, Guo, & O'Hare, 2012; J. H. Yang et al, 2015), catalysts (Lu et al, 2014; Zhao, Wei, Lu, Wang, & Duan, 2009), polymer compounding materials and traditional medicines (Choy, Choi, Oh, & Park, 2007; Choy et al, 2004; Paek, Oh, & Choy, 2011; Ruiz‐Hitzky, 2003), and so on. Owing to the rapid development of nano‐bio convergence technologies, such two‐dimensional (2D) materials were considered to be important nanomedical systems for future use (Alcântara, Aranda, Darder, & Ruiz‐Hitzky, 2010; Chen, Gunawan, Lou, & Xu, 2012; G. Choi, Jeon, Piao, & Choy, 2018; Darder, López‐Blanco, Aranda, Leroux, & Ruiz‐Hitzky, 2005; Jiang et al, 2020; Rocha et al, 2016; S. Wang, Yang, Zhou, Li, & Chen, 2020; Wu et al, 2020). In particular, biocompatible layered double hydroxide (LDH) was challenged as the gene delivery vehicle for the first time in the late 1900 by Choy and his colleagues (Choy et al, 1999), which was indeed the first example of advanced drug delivery system (DDS) based on LDHs.…”

Section: Introductionmentioning

confidence: 99%

Recent progress in layered double hydroxides as a cancer theranostic nanoplatform

Choi

2020

WIREs Nanomed Nanobiotechnol

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Layered double hydroxide (LDH) has been a big challenge in exploring new hybrid materials by intercalating inorganic, organic, or bio molecules into their lamellar lattice, those which often showed dual functions from each other or new mutative properties. Recently, nano‐bio convergence technology becomes one of the most extensively studied research fields in the view point of developing advanced drugs and diagnostic agents to fight against disease and eventually to improve the lives of human beings. Therefore, LDH as one of the nanomaterials have been intensively investigated not only as biocompatible drug delivery vehicle for cancer chemotherapy but also as diagnostic and imaging agents. In the present review, we have attempted to summarize theranostic functions of drug‐LDH hybrid nanoparticles including their synthetic methods, physico‐chemical and biological properties, and their unique mechanism overcoming drug resistance, and targeting properties based on in vitro and finally in vivo results. This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Diagnostic Tools > in vivo Nanodiagnostics and Imaging

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2D nanostructures beyond graphene: preparation, biocompatibility and biodegradation behaviors

Abstract: The research advances of the preparation, biocompatibility and biodegradation of 2D nanomaterials are introduced. The prospects and challenges of the biomedical applications of 2D nanomaterials are summarized.

Cited by 49 publications

References 126 publications

Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review

Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review

Two-Dimensional Nanomaterials With Enzyme-Like Properties for Biomedical Applications

Recent progress in layered double hydroxides as a cancer theranostic nanoplatform

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