2D-titanium carbide (MXene) based selective electrochemical sensor for simultaneous detection of ascorbic acid, dopamine and uric acid

Murugan, Nagaraj; Rajendran, Jerome; Murugan, Preethika; Sundaramurthy, Anandhakumar; Sundramoorthy, Ashok K.

doi:10.1016/j.jmst.2020.07.037

Cited by 141 publications

(46 citation statements)

References 74 publications

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“…In terms of the essential biomolecules, dopamine, ascorbic acid, and uric acid coexist in biological systems and changes in their concentrations can be linked to a number of diseases, such as Parkinson's disease and schizophrenia. Normally, in biological systems dopamine concentrations vary from about 10 nM to 1 µM, ascorbic acid from 1 to 2 mM, and uric acid from 207 to 444 µM [192]. Therefore, their accurate quantification across these concentration ranges in biological fluids is necessary for the clinical diagnosis of various diseases.…”

Section: A Comparison Of the Performance Of The Cyclodextrin Modifiedmentioning

confidence: 99%

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

et al. 2021

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Supramolecular chemistry, although focused mainly on noncovalent intermolecular and intramolecular interactions, which are considerably weaker than covalent interactions, can be employed to fabricate sensors with a remarkable affinity for a target analyte. In this review the development of cyclodextrin-based electrochemical sensors is described and discussed. Following a short introduction to the general properties of cyclodextrins and their ability to form inclusion complexes, the cyclodextrin-based sensors are introduced. This includes the combination of cyclodextrins with reduced graphene oxide, carbon nanotubes, conducting polymers, enzymes and aptamers, and electropolymerized cyclodextrin films. The applications of these materials as chiral recognition agents and biosensors and in the electrochemical detection of environmental contaminants, biomolecules and amino acids, drugs and flavonoids are reviewed and compared. Based on the papers reviewed, it is clear that cyclodextrins are promising molecular recognition agents in the creation of electrochemical sensors, chiral sensors, and biosensors. Moreover, they have been combined with a host of materials to enhance the detection of the target analytes. Nevertheless, challenges remain, including the development of more robust methods for the integration of cyclodextrins into the sensing unit.

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Section: A Comparison Of the Performance Of The Cyclodextrin Modifiedmentioning

confidence: 99%

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

et al. 2021

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“…As reported earlier, the Raman spectrum of the Ti 3 C 2 T x showed the presence of Ti-C, Ti-Al and TiO 2 vibrational bands [ 36 ]. The major Ti 3 C 2 T x vibration bands appeared at 215, 352, 620 and 688 cm −1 [ 29 ], which confirmed the formation of Ti 3 C 2 T x . The Ti-C vibrational bands appeared at 352 [ 29 ], 620 and 688 cm −1 [ 37 ].…”

Section: Resultsmentioning

confidence: 87%

“…Preparation of Ti 3 C 2 T x was carried out as reported elsewhere [ 29 ]. FAD and DA were purchased from the Sigma-Aldrich, Bangalore India.…”

Section: Methodsmentioning

confidence: 99%

“…Due to the peculiar properties of MXenes, they have been used in various applications which include supercapacitors [ 24 ], batteries [ 25 ], microbial fuel cells [ 26 ], photocatalysis [ 27 ] and sensors [ 19 ]. Recently, MXene based electrochemical sensors had been reported for the sensing of glucose [ 28 ], ascorbic acid (AA), dopamine (DA) and uric acid (UA) [ 29 ], L-cysteine [ 30 ] and superoxide anions from human liver cancer cell lines (HepG2) [ 31 ]. In addition, enzymatic [ 32 ] and a non-enzymatic H 2 O 2 sensors were also prepared using the platinum nanoparticle (Pt NPs) decorated MXene [ 33 ] and polyaniline/Pt NPs/MXene modified electrodes [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

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Biocompatible MXene (Ti3C2Tx) Immobilized with Flavin Adenine Dinucleotide as an Electrochemical Transducer for Hydrogen Peroxide Detection in Ovarian Cancer Cell Lines

et al. 2021

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Flavin adenine dinucleotide (FAD) is a coenzyme and acts as a redox cofactor in metabolic process. Owing to such problems as poor electron transfer properties, unfavorable adsorption, and lack of stability on rigid electrodes, the bio-electrochemical applications of FAD have been limited. Herein, a novel fabrication method was developed for the immobilization process using 2D MXene (Ti3C2Tx), which enhanced the redox property of FAD and improved the electro-catalytic reduction of hydrogen peroxide (H2O2) in neutral medium. The FAD-immobilized Ti3C2Tx electrode (FAD/Ti3C2Tx) was studied by UV-Visible and Raman spectroscopies, which confirmed the successful adsorption of FAD on the Ti3C2Tx surface. The surface morphology and the elemental composition of Ti3C2Tx were investigated by high resolution transmission electron microscopy and the energy dispersive X-ray analysis. The redox property of the FAD/Ti3C2Tx modified glassy carbon electrode (FAD/Ti3C2Tx/GCE) was highly dependent on pH and exhibited a stable redox peak at −0.455 V in neutral medium. Higher amounts of FAD molecules were loaded onto the 2D MXene (Ti3C2Tx)-modified electrode, which was two times higher than the values in the reported work, and the surface coverage (ᴦFAD) was 0.8 × 10−10 mol/cm2. The FAD/Ti3C2Tx modified sensor showed the electrocatalytic reduction of H2O2 at −0.47 V, which was 130 mV lower than the bare electrode. The FAD/Ti3C2Tx/GCE sensor showed a linear detection of H2O2 from 5 nM to 2 µM. The optimization of FAD deposition, amount of Ti3C2Tx loading, effect of pH and the interference study with common biochemicals such as glucose, lactose, dopamine (DA), potassium chloride (KCl), ascorbic acid (AA), amino acids, uric acid (UA), oxalic acid (OA), sodium chloride (NaCl) and acetaminophen (PA) have been carried out. The FAD/Ti3C2Tx/GCE showed high selectivity and reproducibility. Finally, the FAD/Ti3C2Tx modified electrode was successfully applied to detect H2O2 in ovarian cancer cell lines.

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“…In addition, the oxidation peak potentials gradually shifted to a high positive potential, which indicated the kinetic limitation of the reaction. 70 The relationship between the nicotine oxidation current and square root of the scan rate (inset of Fig. 7) displayed a linear equation of y = 0.4675x À 0.4137 with a correlation coefficient (r 2 ) of 0.983.…”

Section: The Effect Of Scan Rate On Nicotine Oxidationmentioning

confidence: 97%

An electrochemically exfoliated graphene/poly(3,4-ethylenedioxythiophene) nanocomposite-based electrochemical sensor for the detection of nicotine

2021

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2D-titanium carbide (MXene) based selective electrochemical sensor for simultaneous detection of ascorbic acid, dopamine and uric acid

Cited by 141 publications

References 74 publications

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

Biocompatible MXene (Ti3C2Tx) Immobilized with Flavin Adenine Dinucleotide as an Electrochemical Transducer for Hydrogen Peroxide Detection in Ovarian Cancer Cell Lines

An electrochemically exfoliated graphene/poly(3,4-ethylenedioxythiophene) nanocomposite-based electrochemical sensor for the detection of nicotine

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