2D transition metal dichalcogenide nanomaterial-based miRNA biosensors

Mitrevska, Katerina; Milosavljević, Vedran; Gagić, Milica; Richtera, Lukáš; Adam, Vojtěch

doi:10.1016/j.apmt.2021.101043

Cited by 8 publications

(7 citation statements)

References 167 publications

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“…276 The nanoscale metal dichalcogenide can be used to develop biosensors to detect microRNAs. 277 The properties of these materials have been enhanced by incorporating and combining various metal ions into their structural framework. In this conjunction, recently, Vaghasiya et al 278 fabricated a wearable power patch to monitor the body's glucose level.…”

Section: Flexible and Wearable Biosensorsmentioning

confidence: 99%

Review on Healthcare Biosensing Nanomaterials

Tripathi

Bonilla‐Cruz

2023

ACS Appl. Nano Mater.

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Fast technological progress has sped up the growth of telemedicine, mobile e-health services, and healthcare monitoring, which, nowadays, are technologies in high demand in the medical field and analytical sensing. Biosensing device design has promoted forefront research topics wherein new sensing technologies have been developed. In this regard, nanomaterials have had a crucial role wherein novel biosensors based on nanomaterials have emerged as detective tools for several biomolecules. Most biosensors are remarkably sensitive and selective to detect cancer biomarkers, toxins in foods, drugs, pathogenic microorganisms, cholesterol, pesticides, nucleic acids, glucose, heavy-metal contaminations, and other bioanalytes under different platforms at extraordinarily low concentrations (nanomolar, picomolar, or femtomolar). A comprehensive review of nanomaterials used for healthcare biosensing is offered herein. Specifically, this review offers a new point of view, highlighting and covering exhaustively several kinds of nanomaterials (<500 nm) to detect human diseases through biosensing. In this sense, we organize them into organic, inorganic, and carbon-based, thus offering a guide to selecting the best nanomaterial for specific detection. Further, it provides a roadmap to the real-time utilization of nanomaterials at a commercial scale. Also, this review addresses some crucial aspects of nanomaterials use and applications for healthcare biosensing. The progress discussed in this paper highlights the immense potential to implement the use of nanomaterials and nanocomposites in the initial examination of diseases and point-of-care testing.

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Section: Flexible and Wearable Biosensorsmentioning

confidence: 99%

Review on Healthcare Biosensing Nanomaterials

Tripathi

Bonilla‐Cruz

2023

ACS Appl. Nano Mater.

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“…In another effort, Tellurium@Selenium core-shell heterojunction was fabricated by epitaxial growth Se on Te nanotubes (NTs), which demonstrated strong broadband linear and nonlinear optical response compared to pristine Te-NTs 62 . Other scholars comprehensively investigated the biosensing application of 2D layered materials and the impact of doping on biosensing functionality of these materials [63][64][65] . The enhancement of physicochemical properties of Se have been also extensively explored using its alloying with other compounds such as Te 66 .…”

Section: Selenium Properties and Their Potential In Enhanced Biosensi...mentioning

confidence: 99%

“…62 Other scholars comprehensively investigated the biosensing application of 2D layered materials and the impact of doping on biosensing functionality of these materials. [63][64][65] The enhancement of physicochemical properties of Se have been also extensively explored using its alloying with other compounds such as Te. 66 Functionalization of SeNPs can also transform their bandgap and make them promising candidates for optoelectronic devices.…”

Section: Review Materials Advancesmentioning

confidence: 99%

Selenium-based nanomaterials for biosensing applications

et al. 2022

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“…This technique replaces the samples from tissue to blood or body fluids and requires only a trace amount of biological sample [18][19][20]. For isolated liquid containing dissolved nucleic acids, mature medical detection methods such as RT-qPCR, Northern blotting and microarray analysis have been clinically applied [21][22][23]. Nevertheless, they are limited by low sensitivity, high cost, poor portability and long waiting periods before detection.…”

Section: Introductionmentioning

confidence: 99%

Identification and ultrasensitive photoelectrochemical detection of LncNR_040117: a biomarker of recurrent miscarriage and antiphospholipid antibody syndrome in platelet-derived microparticles

et al. 2022

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The abnormal expression of long non-coding RNAs (LncRNAs) in platelet-derived microparticles (PMPs) is closely related to immune disorders and may lead to antiphospholipid antibody syndrome and recurrent miscarriage. To understand the association between the LncRNAs in PMPs and RM/APS, the differences in the expression of LncRNAs in RM/APS patients and healthy controls were analyzed. Microarray analysis and RT-qPCR detection proved that RM/APS patient exhibited high levels of LncNR_040117 expression. The lentiviral silent expression transfection of HTR-8/SVneo cells indicated that LncNR_040117 downregulation decreased the activity of HTR-8/SVneo cells and inhibited the MAPK signaling pathway, further confirming the biomarker proficiency of LncNR_040117 for RM/APS. After that, we proposed a β-In2S3@g-C3N4 nanoheterojunction-based photoelectrochemical (PEC) biosensor to achieve the ultrasensitive detection of LncNR_040117. The nanoheterojunction aids in the effective separation of photogenerated carriers and significantly improve the photocurrent response of the biosensor. The conjugation of LncNR_040117 onto the PEC biosensing platform increased the steric hindrance between electrolyte and electrode, subsequently decreasing the photocurrent signal. The PEC biosensor showed a wide detection range of 0.1–106 fM and a low limit of detection of 0.025 fM. For clinical sample testing, the results of the PEC and RT-qPCR were highly consistent. Overall, LncNR_040117 in PMPs was identified as an effective biomarker for RM/APS and could be accurately detected by the proposed PEC biosensor, which is expected to provide a reliable diagnostic platform for RM/APS.

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2D transition metal dichalcogenide nanomaterial-based miRNA biosensors

Cited by 8 publications

References 167 publications

Review on Healthcare Biosensing Nanomaterials

Review on Healthcare Biosensing Nanomaterials

Selenium-based nanomaterials for biosensing applications

Identification and ultrasensitive photoelectrochemical detection of LncNR_040117: a biomarker of recurrent miscarriage and antiphospholipid antibody syndrome in platelet-derived microparticles

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